Deng Junhui, Wu Zhifen, He Yun, Lin Lirong, Tan Wei, Yang Jurong
The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China.
The Fifth People's Hospital of Chongqing, Chongqing, China.
Front Med (Lausanne). 2022 Jul 7;9:954574. doi: 10.3389/fmed.2022.954574. eCollection 2022.
A growing number of studies have confirmed that immune cells play various key roles in the pathophysiology of acute kidney injury (AKI) development. After the resident immune cells and intrinsic renal cells are damaged by ischemia and hypoxia, drugs and toxins, more immune cells will be recruited to infiltrate through the release of chemokines, while the intrinsic cells promote macrophage polarity conversion, and the immune cells will promote various programmed deaths, phenotypic conversion and cycle arrest of the intrinsic cells, ultimately leading to renal impairment and fibrosis. In the complex and dynamic immune microenvironment of AKI, the bidirectional interaction between immune cells and intrinsic renal cells affects the prognosis of the kidney and the progression of fibrosis, and determines the ultimate fate of the kidney.
越来越多的研究证实，免疫细胞在急性肾损伤（AKI）发生发展的病理生理学过程中发挥着多种关键作用。在固有免疫细胞和肾实质细胞受到缺血缺氧、药物及毒素损伤后，更多的免疫细胞会通过趋化因子的释放被募集浸润，同时固有细胞促进巨噬细胞极性转换，而免疫细胞会促进固有细胞发生各种程序性死亡、表型转换及周期阻滞，最终导致肾功能损害和纤维化。在AKI复杂且动态的免疫微环境中，免疫细胞与肾实质细胞之间的双向相互作用影响肾脏预后及纤维化进展，并决定肾脏的最终命运。
