Supajaree Pruttaya, Chanprasertyothin Suwannee, Chattranukulchai Shantavasinkul Prapimporn, Sritara Piyamitr, Sirivarasai Jintana
Master of Science Program in Nutrition, Faculty of Medicine Ramathibodi Hospital and Institute of Nutrition, Mahidol University, Bangkok, Thailand.
Research & Innovation, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.
Adv Prev Med. 2022 Jul 14;2022:4930033. doi: 10.1155/2022/4930033. eCollection 2022.
Apolipoprotein A1 (ApoA1) gene polymorphism is linked to high-density lipoprotein cholesterol (HDL-C) levels. Variations in this gene, along with dyslipidemia and inflammation, may increase the risk of vascular stiffness. This study aimed to investigate the link between ApoA1 rs670 genetic variations, various biochemical parameters, and the risk of arterial stiffness in older people.
This population-based cross-sectional study included 355 participants (≥60 years) who completed a demographic and lifestyle information questionnaire. Clinical and anthropometric examination, biochemical analysis, and ApoA1 rs670 genotyping by real-time PCR were performed. The cardio-ankle vascular index (CAVI) was used to assess arterial stiffness.
Age, BMI, waist circumference, SBP, LDL-C, and high-sensitivity C-reactive protein (hs-CRP) were associated with high CAVI (≥9) among older people. The mean CAVI (8.19 ± 2.78) for the ApoA1 rs670 AA genotype was lower than that of the GG genotypes (8.94 ± 1.00, < 0.05). These results are supported by HDL-C (OR = 0.47, 95% CI: 0.24-0.93; =0.030) and high hs-CRP (OR = 0.30, 95% CI: 0.16-0.57; =0.006) levels together with adjusted ORs of both variables.
ApoA1 rs670 genetic variations involved in the synthesis, transport, and processing of HDLs, hypertension, and inflammation are linked to arterial stiffness. Further studies are required to clarify these mechanisms.
载脂蛋白A1（ApoA1）基因多态性与高密度脂蛋白胆固醇（HDL-C）水平相关。该基因的变异，连同血脂异常和炎症，可能会增加血管僵硬的风险。本研究旨在调查ApoA1 rs670基因变异、各种生化参数与老年人动脉僵硬风险之间的联系。
这项基于人群的横断面研究纳入了355名年龄≥60岁的参与者，他们完成了一份人口统计学和生活方式信息问卷。进行了临床和人体测量检查、生化分析以及通过实时聚合酶链反应对ApoA1 rs670进行基因分型。采用心踝血管指数（CAVI）评估动脉僵硬程度。
年龄、体重指数、腰围、收缩压、低密度脂蛋白胆固醇（LDL-C）和高敏C反应蛋白（hs-CRP）与老年人中高CAVI（≥9）相关。ApoA1 rs670 AA基因型的平均CAVI（8.19±2.78）低于GG基因型（8.94±1.00，P<0.05）。HDL-C（比值比[OR]=0.47，95%置信区间[CI]：0.24 - 0.93；P=0.030）和高hs-CRP（OR=0.30，95% CI：0.16 - 0.57；P=0.006）水平以及这两个变量的校正OR值均支持这些结果。
参与HDL合成、运输和加工的ApoA1 rs670基因变异、高血压和炎症与动脉僵硬有关。需要进一步研究来阐明这些机制。
