Department of Biochemistry/Clinical Biochemistry, University of Kashmir, Srinagar, India.
Department of Endocrinology, Government Medical College, Shireen Bagh, Srinagar, India.
Diabetes Metab Syndr. 2021 May-Jun;15(3):803-811. doi: 10.1016/j.dsx.2021.03.031. Epub 2021 Mar 31.
A large number of chemical compounds with endocrine-disrupting activity have been documented. These chemicals are ubiquitous and widely used in many products of our daily lives. Bisphenol A (BPA) is among the most common Endocrine Disrupting Chemical (EDC) that has been used for many years in the manufacture of polycarbonate plastics and epoxy resins. There is growing evidence that exposure to these EDCs poses a possible health risk. This review focuses on the effect of EDCs, in particular, BPA on female reproduction and Polycystic Ovary Syndrome (PCOS), which is the most prevalent endocrine disorder of reproductively aged women.
A relevant literature survey was conducted with Google scholar and Pubmed using several appropriate keywords to select the most relevant studies evaluating the role of endocrine disrupting-chemicals in female reproduction.
The female menstrual cycle and fertility are very sensitive to hormonal imbalance and alteration in endocrine function during critical times and different stages of lifecycle owing to EDC exposure results in many abnormalities like menstrual irregularities, impaired fertility, PCOS, and Endometriosis among others. BPA is the most extensively studied EDC worldwide and has been strongly associated with female reproductive health.
EDCs lead to deleterious effects on human health including reproductive health which are of global concern. Exposure to EDCs in early life can elicit disease in adult life and maybe even transgenerational. There is an immediate need to minimize the ill effect of EDCs which can be tackled through the collection of more data to clarify the clinical implications of EDCs.
大量具有内分泌干扰活性的化学物质已经被记录在案。这些化学物质无处不在，广泛应用于我们日常生活中的许多产品中。双酚 A（BPA）是最常见的内分泌干扰化学物质（EDC）之一，多年来一直用于制造聚碳酸酯塑料和环氧树脂。越来越多的证据表明，接触这些 EDC 可能会对健康造成潜在风险。本综述重点关注 EDC，特别是 BPA 对女性生殖和多囊卵巢综合征（PCOS）的影响，PCOS 是生殖年龄妇女最常见的内分泌疾病。
通过 Google Scholar 和 Pubmed 进行了相关文献调查，使用了几个适当的关键词来选择评估内分泌干扰化学物质在女性生殖中的作用的最相关研究。
女性的月经周期和生育能力对激素失衡和内分泌功能改变非常敏感，在生命周期的关键时期和不同阶段，由于 EDC 暴露会导致许多异常，如月经不规律、生育能力受损、PCOS 和子宫内膜异位症等。BPA 是全球研究最广泛的 EDC，与女性生殖健康密切相关。
EDC 会对人类健康造成有害影响，包括生殖健康，这是全球关注的问题。在生命早期接触 EDC 会在成年期引发疾病，甚至可能会发生代际传递。目前迫切需要通过收集更多数据来阐明 EDC 的临床意义，以最大限度地减少 EDC 的不良影响。
