辛伐他汀治疗结直肠癌：综述
Simvastatin in the Treatment of Colorectal Cancer: A Review.
作者信息
Zang Hongliang, Yang Wei, Tian Xiaofeng
机构信息
Department of Hepatopancreatobiliary Surgery, China-Japan Union Hospital of Jilin University, Changchun, China.
出版信息
Evid Based Complement Alternat Med. 2022 Jul 14;2022:3827933. doi: 10.1155/2022/3827933. eCollection 2022.
Abstract
Drug repositioning and drug reuse are the heated topics in the field of oncology in recent years. These two concepts refer to seeking effective drugs for cancer that are not originally intended to treat cancer. The survival benefits are then analyzed by combining the re-positioned drugs with conventional cancer treatment methods. Simvastatin is a clinically commonly used hyperlipidemia drug and exerts the effect of preventing cardiovascular diseases. Recent studies have found that simvastatin has great potential in the treatment of colorectal cancer, and a large number of clinical studies have used simvastatin as an adjuvant drug to help treat metastatic colorectal cancer.
摘要
药物重新定位和药物再利用是近年来肿瘤学领域的热门话题。这两个概念是指寻找原本并非用于治疗癌症的有效抗癌药物。然后将重新定位的药物与传统癌症治疗方法相结合，分析其对患者生存的益处。辛伐他汀是一种临床常用的降血脂药物，具有预防心血管疾病的作用。最近的研究发现，辛伐他汀在结直肠癌治疗中具有巨大潜力，大量临床研究已将辛伐他汀用作辅助药物来帮助治疗转移性结直肠癌。
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