Turgay Türkan, Denkçeken Tuba, Maralcan Göktürk
Department of Physical Medicine and Rehabilitation, Sanko University Faculty of Medicine, Gaziantep, Turkey.
Department of Biophysics, Sanko University Faculty of Medicine, Gaziantep, Turkey.
Turk J Surg. 2022 Mar 28;38(1):11-17. doi: 10.47717/turkjsurg.2022.5550. eCollection 2022 Mar.
The correlation between lymphedema severity and stages determined by standard diagnostic methods and Bioimpedance Spectroscopy (BIS) technique was examined in breast cancer-related lymphedema (BCRL) patients.
The bioimpedance analyzer device was connected to the 1.0 cm disc electrodes which were connected to the affected and unaffected (healthy) arm of the patients. We evaluated the performance of the impedance (Z) at multiple frequencies (5-50-100-200 kHz) and phase angle (PA), resistance (R), and reactance (XC) at 50 kHz on the lymphedema severity and stages. Bioimpedance measurements were applied to all volunteers in cooperation with the Physical Therapy and Rehabilitation Department. In this study, the correlation between BCRL severity and stages and bioimpedance values was examined.
A total of 31 female patients were recruited to compare the BIS technique with standard diagnostic techniques. The severity of lymphedema was found among the patients as follows; mild 14 (45.2%), moderate 10 (32.3%), and severe 7 (22.6%). The stage distribution of volunteers was; 15 (48.4%) patients in Stage 0, 10 (32.3%) patients in Stage 1, 5 (16.1%) patients in Stage 2, and 1 (3.2%) patient in Stage 3. The ratio of affected and unaffected arm bioimpedance mean values were calculated. Although, this ratio at 50-100-200 kHz Z and 50kHz R were significantly correlated with the lymphedema stages (p <0.05), there was no correlation and significant difference between the ratio of the bioimpedance values and lymphedema severity (p> 0.05).
The BIS technique is timesaving and can determine lymphedema stages. We found a significant correlation between BCRL stages and BIS, and it appears that BIS is an appropriate, inexpensive, simple, and noninvasive technique for detecting the stages of BCRL.
在乳腺癌相关淋巴水肿（BCRL）患者中，研究标准诊断方法和生物电阻抗光谱（BIS）技术所确定的淋巴水肿严重程度与分期之间的相关性。
将生物电阻抗分析仪设备连接到1.0厘米的圆盘电极上，该电极与患者受影响和未受影响（健康）的手臂相连。我们评估了多个频率（5 - 50 - 100 - 200千赫兹）下的阻抗（Z）以及50千赫兹时的相角（PA）、电阻（R）和电抗（XC）对淋巴水肿严重程度和分期的影响。生物电阻抗测量在物理治疗与康复科的配合下应用于所有志愿者。在本研究中，检测了BCRL严重程度和分期与生物电阻抗值之间的相关性。
共招募了31名女性患者，以比较BIS技术与标准诊断技术。患者中淋巴水肿的严重程度如下：轻度14例（45.2%），中度10例（32.3%），重度7例（22.6%）。志愿者的分期分布为：0期15例（48.4%），1期10例（32.3%），2期5例（16.1%），3期1例（3.2%）。计算了患侧和未患侧手臂生物电阻抗平均值的比率。尽管50 - 100 - 200千赫兹Z和50千赫兹R时的该比率与淋巴水肿分期显著相关（p <0.05），但生物电阻抗值的比率与淋巴水肿严重程度之间无相关性且无显著差异（p> 0.05）。
BIS技术省时且能确定淋巴水肿分期。我们发现BCRL分期与BIS之间存在显著相关性，似乎BIS是一种用于检测BCRL分期的合适、廉价、简单且无创的技术。
