Kim Leesuk, Jeon Jae Yong, Sung In Young, Jeong Soon Yong, Do Jung Hwa, Kim Hwa Jung
Department of Rehabilitation Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 138-736, Korea.
Ann Rehabil Med. 2011 Oct;35(5):687-93. doi: 10.5535/arm.2011.35.5.687. Epub 2011 Oct 31.
To investigate the usefulness of bioimpedance measurement for predicting the treatment outcome in breast cancer related lymphedema (BCRL) patients.
Unilateral BCRL patients who received complex decongestive therapy (CDT) for 2 weeks (5 days per week) were enrolled in this study. We measured the ratio of extracellular fluid (ECF) volume by using bioelectrical impedance spectroscopy (BIS), and single frequency bioimpedance analysis (SFBIA) at a 5 kHz frequency before treatment. Arm circumferences were measured at 10 cm above and below the elbow before and after treatment. We also investigated whether there is correlation between ECF ratio and SFBIA ratio with the change of arm circumference after CDT.
A total of 73 patients were enrolled in this study. The higher ECF ratio was significantly correlated with higher reduction of arm circumference at both above and below the elbow after treatment, but the higher SFBIA ratio was correlated only with the higher reduction of arm circumference below the elbow.
These results show that ECF volume measurements and SFBIA before treatment are useful tools for predicting the outcome of patients with lymphedema. We concluded that ECF volume measure can be used as a screening tool for predicting treatment outcome of BCRL patients.
探讨生物阻抗测量在预测乳腺癌相关淋巴水肿（BCRL）患者治疗效果方面的作用。
本研究纳入了接受为期2周（每周5天）综合消肿治疗（CDT）的单侧BCRL患者。在治疗前，我们使用生物电阻抗光谱法（BIS）和5 kHz频率的单频生物阻抗分析（SFBIA）测量细胞外液（ECF）体积比。在治疗前后测量肘部上方和下方10 cm处的手臂周长。我们还研究了CDT后ECF比率和SFBIA比率与手臂周长变化之间是否存在相关性。
本研究共纳入73例患者。较高的ECF比率与治疗后肘部上方和下方手臂周长的更大减少显著相关，但较高的SFBIA比率仅与肘部下方手臂周长的更大减少相关。
这些结果表明，治疗前的ECF体积测量和SFBIA是预测淋巴水肿患者治疗效果的有用工具。我们得出结论，ECF体积测量可作为预测BCRL患者治疗效果的筛查工具。
