Yu Rui, Zhang Hualei, Guo Baolin
State Key Laboratory for Mechanical Behavior of Materials, and Frontier Institute of Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.
Key Laboratory of Shaanxi Province for Craniofacial Precision Medicine Research, College of Stomatology, Xi'an Jiaotong University, Xi'an, 710049, People's Republic of China.
Nanomicro Lett. 2021 Dec 2;14(1):1. doi: 10.1007/s40820-021-00751-y.
Conductive biomaterials based on conductive polymers, carbon nanomaterials, or conductive inorganic nanomaterials demonstrate great potential in wound healing and skin tissue engineering, owing to the similar conductivity to human skin, good antioxidant and antibacterial activities, electrically controlled drug delivery, and photothermal effect. However, a review highlights the design and application of conductive biomaterials for wound healing and skin tissue engineering is lacking. In this review, the design and fabrication methods of conductive biomaterials with various structural forms including film, nanofiber, membrane, hydrogel, sponge, foam, and acellular dermal matrix for applications in wound healing and skin tissue engineering and the corresponding mechanism in promoting the healing process were summarized. The approaches that conductive biomaterials realize their great value in healing wounds via three main strategies (electrotherapy, wound dressing, and wound assessment) were reviewed. The application of conductive biomaterials as wound dressing when facing different wounds including acute wound and chronic wound (infected wound and diabetic wound) and for wound monitoring is discussed in detail. The challenges and perspectives in designing and developing multifunctional conductive biomaterials are proposed as well.
基于导电聚合物、碳纳米材料或导电无机纳米材料的导电生物材料在伤口愈合和皮肤组织工程中展现出巨大潜力，这归因于其与人体皮肤相似的导电性、良好的抗氧化和抗菌活性、电控药物递送以及光热效应。然而，一篇综述强调了目前缺乏关于用于伤口愈合和皮肤组织工程的导电生物材料的设计与应用方面的内容。在本综述中，总结了具有各种结构形式（包括薄膜、纳米纤维、膜、水凝胶、海绵、泡沫和脱细胞真皮基质）的导电生物材料在伤口愈合和皮肤组织工程中的设计与制造方法，以及其促进愈合过程的相应机制。回顾了导电生物材料通过三种主要策略（电疗法、伤口敷料和伤口评估）在伤口愈合中实现其巨大价值的途径。详细讨论了导电生物材料在面对不同伤口（包括急性伤口和慢性伤口，如感染伤口和糖尿病伤口）时作为伤口敷料以及用于伤口监测的应用情况。同时也提出了设计和开发多功能导电生物材料所面临的挑战与前景。
