Rentería I, García-Suárez P C, Fry A C, Moncada-Jiménez J, Machado-Parra J P, Antunes B M, Jiménez-Maldonado A
Facultad de Deportes, Universidad Autónoma de Baja California, Ensenada, Mexico.
Department of Health, Sports and Exercise Sciences, University of Kansas, Lawrence, KS, United States.
Front Physiol. 2022 Jul 6;13:934714. doi: 10.3389/fphys.2022.934714. eCollection 2022.
The brain-derived neurotrophic factor (BDNF) is a member of the nerve growth factor family which is generated mainly by the brain. Its main role involve synaptic modulation, neurogenesis, neuron survival, immune regulation, myocardial contraction, and angiogenesis in the brain. Together with the encephalon, some peripheral tissues synthesize BDNF like skeletal muscle. On this tissue, this neurotrophin participates on cellular mechanisms related to muscle function maintenance and plasticity as reported on recent scientific works. Moreover, during exercise stimuli the BDNF contributes directly to strengthening neuromuscular junctions, muscle regeneration, insulin-regulated glucose uptake and -oxidation processes in muscle tissue. Given its vital relevance on many physiological mechanisms, the current mini-review focuses on discussing up-to-date knowledge about BDNF production in skeletal muscle and how this neurotrophin impacts skeletal muscle biology.
脑源性神经营养因子（BDNF）是神经生长因子家族的一员，主要由大脑产生。其主要作用包括突触调节、神经发生、神经元存活、免疫调节、心肌收缩以及大脑中的血管生成。除了脑之外，一些外周组织如骨骼肌也能合成BDNF。正如最近的科学研究报道，在该组织中，这种神经营养因子参与了与肌肉功能维持和可塑性相关的细胞机制。此外，在运动刺激过程中，BDNF直接有助于加强神经肌肉接头、促进肌肉再生、调节胰岛素介导的肌肉组织葡萄糖摄取和氧化过程。鉴于其在许多生理机制中的重要相关性，本综述聚焦于讨论有关骨骼肌中BDNF产生的最新知识，以及这种神经营养因子如何影响骨骼肌生物学。
