Facultad de Deportes Campus Ensenada, Universidad Autónoma de Baja California, 22890, Ensenada, Baja California, México.
Department of Human Studies, University of Alabama at Birmingham, Birmingham, 35294, USA.
Sci Rep. 2021 Apr 26;11(1):8937. doi: 10.1038/s41598-021-88496-x.
The aim of the current meta-analysis was to determine the effects of acute and chronic interval training (IT) on serum and plasma BDNF concentrations in healthy young adults. A literature search was performed using six databases until February 2020. The TESTEX scale was used to assess the quality of studies. Effect sizes (ES) were computed and two-tailed α values < 0.05 and non-overlapping 95% confidence intervals (95% CI) were considered statistically significant. Heterogeneity, inconsistency (I), and small-study effects using the Luis Furuya-Kanamori (LFK) index were examined. Fifteen studies (n = 277 participants, age = 24 ± 3 years) were included. The overall effects of IT on circulating BDNF concentrations were moderate and significant (ES = 0.62, 95% CI 0.00, 1.24, heterogeneous (p < 0.001), highly inconsistent (I = 90%), and with major asymmetry (LFK index = 2.76). The acute effect of IT on peripheral BDNF levels was large and significant (ES = 1.10, 95% CI 0.07, 2.14), heterogeneous (p < 0.001), highly inconsistent (I = 92%), and with major asymmetry (LFK index = 3.34). The chronic effect of IT on circulating BDNF was large and significant (ES = 0.93, 95% CI 0.40, 1.46), heterogeneous (p < 0.001), with moderate inconsistency (I = 70%), and minor asymmetry (LFK index = 1.21). Acute and chronic IT elicited a moderate increase in serum and plasma BDNF concentrations in a healthy young population.
本次荟萃分析的目的是确定急性和慢性间歇训练（IT）对健康年轻成年人血清和血浆 BDNF 浓度的影响。使用六个数据库进行文献检索，直到 2020 年 2 月。使用 TESTEX 量表评估研究质量。计算效应大小（ES），并认为双侧 α 值 < 0.05 和非重叠的 95%置信区间（95%CI）具有统计学意义。使用 Luis Furuya-Kanamori（LFK）指数检查异质性、不一致性（I）和小样本效应。纳入了 15 项研究（n=277 名参与者，年龄=24±3 岁）。IT 对循环 BDNF 浓度的总体影响是中度和显著的（ES=0.62，95%CI 0.00，1.24，异质性（p<0.001），高度不一致（I=90%），且存在严重不对称性（LFK 指数=2.76）。IT 对周围 BDNF 水平的急性影响是大而显著的（ES=1.10，95%CI 0.07，2.14），异质性（p<0.001），高度不一致（I=92%），且存在严重不对称性（LFK 指数=3.34）。IT 对循环 BDNF 的慢性影响是大而显著的（ES=0.93，95%CI 0.40，1.46），异质性（p<0.001），中度不一致（I=70%），且轻微不对称性（LFK 指数=1.21）。急性和慢性 IT 可使健康年轻人群的血清和血浆 BDNF 浓度适度增加。
