Faculty of Health Sciences, University of Macau, Macao SAR, China.
Ministry of Education-Frontiers Science Center for Precision Oncology, University of Macau, Taipa, Macao SAR, China.
Int J Biol Sci. 2022 Jul 11;18(12):4642-4647. doi: 10.7150/ijbs.72424. eCollection 2022.
The coronavirus disease 19 (COVID-19) has been rampant since 2019, severely affecting global public health, and causing 5.75 million deaths worldwide. So far, many vaccines have been developed to prevent the infection of SARS-CoV-2 virus. However, the emergence of new variants may threat vaccine recipients as they might evade immunological surveillance that depends on the using of anti-SARS-CoV-2 antibody to neutralize the viral particles. Recent studies have found that recipients who received two doses of vaccination plus an additional booster shoot were able to quickly elevate neutralization response and immune response against wild-type SARS-CoV-2 virus and some initially appeared viral variants. In this review, we assessed the real-world effectiveness of different COVID-19 vaccines by population studies and neutralization assays and compared neutralization responses of booster vaccines . Finally, as the efficacy of COVID-19 vaccine is expected to decline over time, continued vaccination should be considered to achieve a long-term immune protection against coronavirus.
自 2019 年以来，新型冠状病毒病（COVID-19）肆虐，严重影响全球公共卫生，导致全球 575 万人死亡。到目前为止，已经开发出许多疫苗来预防 SARS-CoV-2 病毒感染。然而，新变种的出现可能会威胁到疫苗接种者，因为它们可能逃避依赖于使用抗 SARS-CoV-2 抗体来中和病毒颗粒的免疫监测。最近的研究发现，接受两剂疫苗接种加一剂加强针的接种者能够迅速提高对野生型 SARS-CoV-2 病毒和一些最初出现的病毒变种的中和反应和免疫反应。在这篇综述中，我们通过人群研究和中和试验评估了不同 COVID-19 疫苗的真实世界效果，并比较了加强疫苗的中和反应。最后，由于 COVID-19 疫苗的疗效预计会随着时间的推移而下降，因此应考虑继续接种疫苗，以实现对冠状病毒的长期免疫保护。
