School of Public Health, Cheeloo College of Medicine, Shandong University, Jinan, China.
Department of Poisoning and Occupational Diseases, Emergency Medicine, Qilu Hospital of Shandong University, Cheeloo College of Medicine, Shandong University, Jinan, China.
Front Public Health. 2022 Jul 7;10:942003. doi: 10.3389/fpubh.2022.942003. eCollection 2022.
5-bromo-2-nitropyridine, an intermediate in the synthesis of pharmaceutical and pesticide products, is toxic to the human body. However, 5-bromo-2-nitropyridine poisoning has not been previously reported. Here, we report the case of a 40-year-old man who suffered skin and respiratory tract exposure to leaked 5-Bromo-2-nitropyridine at work. After exposure, the patient rapidly developed dizziness, fatigue, nausea, vomiting, chest distress, diffuse cyanosis, and coma. Methemoglobinemia, hemolytic anemia, rhabdomyolysis, and acute renal failure were observed after admission. He improved markedly after treatment, but delayed encephalopathy was confirmed 82 days after the exposure. This case highlights that 5-bromo-2-nitropyridine can be absorbed through the skin and respiratory tract, resulting in methemoglobinemia and delayed encephalopathy.
5-溴-2-硝基吡啶是一种用于合成医药和农药产品的中间体，对人体有毒。然而，5-溴-2-硝基吡啶中毒以前并未有报道。在此，我们报告了一例 40 岁男性患者，他在工作中皮肤和呼吸道接触到泄漏的 5-溴-2-硝基吡啶。接触后，患者迅速出现头晕、乏力、恶心、呕吐、胸闷、全身发绀和昏迷。入院后发现患者有高铁血红蛋白血症、溶血性贫血、横纹肌溶解和急性肾衰竭。经过治疗，患者病情明显改善，但在接触后 82 天确诊为迟发性脑病。该病例提示 5-溴-2-硝基吡啶可通过皮肤和呼吸道吸收，导致高铁血红蛋白血症和迟发性脑病。
