Department of Intensive Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan 430030, China.
Department of Emergency, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Hankou, Wuhan 430030, China.
Int J Environ Res Public Health. 2022 Oct 28;19(21):14031. doi: 10.3390/ijerph192114031.
The aromatic amino compound 5-amino-2-(trifluoromethyl)pyridine acts as an intermediate in the synthesis of pharmaceutical products. However, the toxicity profile of this compound is sparse and no related poisoning events have been reported. Here, we report the case of a 35-year-old man who inhaled 5-amino-2-(trifluoromethyl)pyridine at work. After inhalation, the patient rapidly developed symptoms such as dizziness, fatigue, nausea, vomiting, chest tightness, and loss of consciousness. After admission, methemoglobinemia, hemolytic anemia, acute renal failure, and toxic encephalopathy occurred. Symptoms improved significantly after intravenous treatment with a low dose of methylene blue. This revealed that 5-amino-2-(trifluoromethyl)pyridine is toxic to the human body and can be absorbed through the respiratory tract, resulting in methemoglobinemia and toxic encephalopathy; thus, caution should be taken in industrial production.
芳香族氨基化合物 5-氨基-2-(三氟甲基)吡啶是合成药物产品的中间体。然而，该化合物的毒性特征尚不清楚，也没有相关的中毒事件报道。在这里，我们报告了一例 35 岁男性在工作中吸入 5-氨基-2-(三氟甲基)吡啶的病例。吸入后，患者迅速出现头晕、乏力、恶心、呕吐、胸闷和意识丧失等症状。入院后，患者发生高铁血红蛋白血症、溶血性贫血、急性肾衰竭和中毒性脑病。经小剂量亚甲蓝静脉治疗后，症状明显改善。这表明 5-氨基-2-(三氟甲基)吡啶对人体有毒，可通过呼吸道吸收，导致高铁血红蛋白血症和中毒性脑病；因此，在工业生产中应谨慎使用。
