Poudel Jaishi Prakash, Neupane Sandhya Kiran, Neupane Prabhat Kiran, Koirala Divya, Kandel Arjun, Joshi Kushum
General Practitioner, Al Kamil Health Center, Al Kamil, South Sharqiyah, Oman.
Department of Medicine, Shadhak Polyclinic, Bhaktapur, Nepal.
Ann Med Surg (Lond). 2022 Aug;80:104204. doi: 10.1016/j.amsu.2022.104204. Epub 2022 Jul 20.
Subacute thyroiditis (SAT) is a self-limiting viral or post-viral thyroid illness with triphasic clinical history of thyrotoxicosis, hypothyroidism and restoration to normal thyroid function. COVID-19 have wide range of clinical manifestation involving both respiratory and non-respiratory symptoms. Subacute Thyroiditis is one of the emerging symptoms of COVID-19 infection. We reviewed various articles from different online platforms and found that viral antigen binds to HLA B35 molecules on the macrophages which activates cytotoxic T lymphocytes which damage the thyroid follicular cells by binding to ACE2 receptors.
We presented a case of COVID-19 induced subacute thyroiditis in an unvaccinated male patient whose physical symptoms manifested in the second week of infection. He presented with History of difficulty breathing associated with increased perspiration, generalized body weakness.
His clinical Findings and laboratory finding were suggestive of subacute thyroiditis.
The patient had been followed for a period of 15 days and was treated effectively with steroids which improved his symptoms. He was also counseled for vaccination.
亚急性甲状腺炎（SAT）是一种自限性病毒感染或病毒感染后引发的甲状腺疾病，具有甲状腺毒症、甲状腺功能减退以及甲状腺功能恢复正常的三相临床病程。新型冠状病毒肺炎（COVID-19）有广泛的临床表现，涉及呼吸道和非呼吸道症状。亚急性甲状腺炎是COVID-19感染的新出现症状之一。我们查阅了不同在线平台上的各类文章，发现病毒抗原与巨噬细胞上的HLA B35分子结合，激活细胞毒性T淋巴细胞，后者通过与血管紧张素转换酶2（ACE2）受体结合来损伤甲状腺滤泡细胞。
我们报告了一例未接种疫苗的男性患者因COVID-19引发亚急性甲状腺炎的病例，其身体症状在感染后第二周出现。他表现出呼吸困难史，伴有出汗增多、全身乏力。
他的临床发现和实验室检查结果提示为亚急性甲状腺炎。
对该患者进行了为期15天的随访，用类固醇进行有效治疗后症状得到改善。还对他进行了疫苗接种咨询。
