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胆管癌患者全身免疫炎症指数的预后意义：一项荟萃分析

Prognostic Significance of the Systemic Immune-Inflammation Index in Patients With Cholangiocarcinoma: A Meta-Analysis.

作者信息

Liu Xue-Chun, Jiang Yue-Ping, Sun Xue-Guo, Zhao Jian-Jian, Zhang Ling-Yun, Jing Xue

机构信息

Department of Gastroenterology, The Affiliated hospital of Qingdao University, Qingdao, China.

出版信息

Front Oncol. 2022 Jul 7;12:938549. doi: 10.3389/fonc.2022.938549. eCollection 2022.

DOI:10.3389/fonc.2022.938549
PMID:35875153
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9300870/
Abstract

BACKGROUND

The systemic immune-inflammation index (SII) is a significant prognostic factor for neoplastic diseases. However, the prognostic value of SII in patients with cholangiocarcinoma (CCA) remains unclear. This meta-analysis aimed to investigate the prognostic value of preoperative SII in patients with CCA.

METHOD

We systematically searched for relevant studies in PubMed, Scopus, EMBASE, Web of Science, PROSPERO, and Cochrane Library databases up to March 22, 2022. Hazard ratios (HRs) and 95% confidence intervals (CIs) were used to estimate the association between SII and survival outcomes, including overall survival (OS) and recurrence-free survival.

RESULTS

Five studies with 1402 patients were included in this meta-analysis to determine the prognostic value of preoperative SII. The results showed that a higher SII was associated with poor OS in patients with CCA who underwent invasive surgery (HR=1.916; 95% CI, 1.566-2.343; Z=6.329; <0.001). The results were reliable in the subgroup analysis according to country, age, sample size, SII cutoff values, and treatment methods.

CONCLUSIONS

A high preoperative SII appears to be an effective and practical method for monitoring survival in patients with CCA.

SYSTEMATIC REVIEW REGISTRATION

International Platform of Registered Systematic. Review and Meta-Analysis Protocols (INPLASY), identifier INPLASY202240015.

摘要

背景

全身免疫炎症指数（SII）是肿瘤性疾病的一个重要预后因素。然而，SII在胆管癌（CCA）患者中的预后价值仍不明确。本荟萃分析旨在探讨术前SII在CCA患者中的预后价值。

方法

我们系统检索了截至2022年3月22日的PubMed、Scopus、EMBASE、Web of Science、PROSPERO和Cochrane图书馆数据库中的相关研究。采用风险比（HRs）和95%置信区间（CIs）来估计SII与生存结局之间的关联，包括总生存期（OS）和无复发生存期。

结果

本荟萃分析纳入了5项研究中的1402例患者，以确定术前SII的预后价值。结果显示，在接受侵入性手术的CCA患者中，较高的SII与较差的OS相关（HR=1.916；95%CI，1.566-2.343；Z=6.329；<0.001）。根据国家、年龄、样本量、SII临界值和治疗方法进行的亚组分析中，结果是可靠的。

结论

术前高SII似乎是监测CCA患者生存情况的一种有效且实用的方法。

系统评价注册

国际注册系统评价和荟萃分析方案平台（INPLASY），标识符INPLASY202240015。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/00a5/9300870/f4eeb6acd24c/fonc-12-938549-g006.jpg
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