Kale Jyoti S, Katole Nilesh T, Rode Sonali B, Gade Shubhada A
Department of Physiology, Datta Meghe Medical College, Datta Meghe Institute of Medical Sciences (DMIMS) Deemed to be University (DU), Nagpur, IND.
Department of Pharmacology, Datta Meghe Medical College, Datta Meghe Institute of Medical Sciences (DMIMS) Deemed to be University (DU), Nagpur, IND.
Cureus. 2022 Jun 19;14(6):e26074. doi: 10.7759/cureus.26074. eCollection 2022 Jun.
Introduction Thyroid hormones play a crucial role in the proper functioning of the nervous system. Both T3 and T4 hormones have many significant actions on the neuromuscular system and brain. In hypothyroid patients, various neurological signs and symptoms such as weakness, fatigue, paresthesias, arthralgias, etc. may be seen. Reaction time is a good indicator of the processing of the central nervous system. So, our study aims to observe the change in reaction time in hypothyroid patients as compared to the control group. And to understand, if some difference is observed, how does it change after treatment with thyroxin in a hypothyroid group. Materials and methods This study was conducted at the tertiary care teaching hospital in the Vidarbha region. In this study, 40 newly diagnosed primary hypothyroid patients (including males and females), in the age group of 20 to 45 years, and whose thyroid-stimulating hormone (TSH) levels were between 10 and 50 mIU/L and free T4 levels below the normal level were included. A suitable comparable control group of the same demographic parameter was selected. Reaction time was taken before the start of thyroxin treatment in both groups, and results were analyzed by using an unpaired t-test. The reaction time of the hypothyroid group was again measured after eight weeks of the start of thyroxin treatment, it was compared with the initial reaction time, and data were compared by using the paired t-test. Result In the hypothyroid group as compared to the control group both auditory and visual reaction times were significantly on the higher side (p<0.05). Also, there was a significant improvement in reaction time after the start of thyroxin treatment (p<0.05), which suggests improvement in CNS activity in hypothyroid patients after initiation of therapy. Conclusion Thyroid hormones play a crucial role in the proper functioning and processing of the central nervous system. Due to this reason, reaction time in hypothyroid patients was on the longer side, showing a slowing of the nervous system when reacting to a specific stimulus. After thyroxin treatment for a sufficient period, reaction times were of shorter duration as compared to before the start of thyroxin, which shows well-recovered nervous activity. Therefore, reaction time is not only used as a handy tool to identify early central nervous system manifestations of hypothyroidism but also used to monitor response to treatment.
引言
甲状腺激素在神经系统的正常运作中起着至关重要的作用。T3和T4激素对神经肌肉系统和大脑都有许多重要作用。在甲状腺功能减退的患者中，可能会出现各种神经体征和症状，如虚弱、疲劳、感觉异常、关节痛等。反应时间是中枢神经系统处理能力的一个良好指标。因此，我们的研究旨在观察甲状腺功能减退患者与对照组相比反应时间的变化。并了解，如果观察到有差异，甲状腺功能减退组在使用甲状腺素治疗后反应时间如何变化。
材料与方法
本研究在维达巴地区的三级护理教学医院进行。在本研究中，纳入了40例新诊断的原发性甲状腺功能减退患者（包括男性和女性），年龄在20至45岁之间，促甲状腺激素（TSH）水平在10至50 mIU/L之间且游离T4水平低于正常水平。选择了具有相同人口统计学参数的合适可比对照组。两组均在开始甲状腺素治疗前测量反应时间，并使用非配对t检验分析结果。甲状腺功能减退组在开始甲状腺素治疗八周后再次测量反应时间，将其与初始反应时间进行比较，并使用配对t检验比较数据。
结果
与对照组相比，甲状腺功能减退组的听觉和视觉反应时间均显著偏高（p<0.05）。此外，开始甲状腺素治疗后反应时间有显著改善（p<0.05），这表明甲状腺功能减退患者在开始治疗后中枢神经系统活动有所改善。
结论
甲状腺激素在中枢神经系统的正常运作和处理中起着至关重要的作用。因此，甲状腺功能减退患者的反应时间较长，表明在对特定刺激做出反应时神经系统减慢。在进行足够长时间的甲状腺素治疗后，与开始甲状腺素治疗前相比，反应时间缩短，这表明神经活动恢复良好。因此，反应时间不仅可作为识别甲状腺功能减退早期中枢神经系统表现的便捷工具，还可用于监测治疗反应。
