Ma Yingjian, Mao Jing, Qin Haojie, Liang Pan, Huang Wenpeng, Liu Chenchen, Gao Jianbo
Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, China.
Front Bioeng Biotechnol. 2022 Jul 6;10:927461. doi: 10.3389/fbioe.2022.927461. eCollection 2022.
The multifunctional theranostic nanoplatforms, which can realize changing the contrasts of medical images and enhance cancer therapies simultaneously, have attracted tremendous attention from chemists and medicine in past decades. Herein, a nanoscale metal-organic framework-based material was first synthesized and then decorated with platinum (NMOF545@Pt) successfully for multimodal imaging-guided synergistic cancer therapy. The obtained NMOF545@Pt is advantageous in shortening the longitudinal relaxation time (T1), enhancing photoacoustic effects, and elevating X-ray absorption efficiently. Thus, the enchantments of tripe imaging modalities, computed tomography (CT)/magnetic resonance imaging (MRI)/photoacoustic imaging (PAI), were realized with NMOF545@Pt administration simultaneously and can be cleared from the mice. Meanwhile, and experiments demonstrate that the synthesized NMOF545@Pt can dramatically increase photothermal therapy (PTT) and radiotherapy (RT) efficacy. Convincing evidence proves that tumor growth can be wholly inhibited without noticeable side effects or organ damage. The results demonstrated the promise of multifunctional nanocomposites NMOF545@Pt to improve biomedical imaging and synergistic tumor treatments.
多功能诊疗纳米平台能够同时实现改变医学图像对比度和增强癌症治疗效果，在过去几十年中引起了化学家和医学领域的极大关注。在此，首先合成了一种基于纳米级金属有机框架的材料，然后成功地用铂进行修饰（NMOF545@Pt），用于多模态成像引导的协同癌症治疗。所获得的NMOF545@Pt在缩短纵向弛豫时间（T1）、增强光声效应以及有效提高X射线吸收方面具有优势。因此，通过同时给予NMOF545@Pt实现了计算机断层扫描（CT）/磁共振成像（MRI）/光声成像（PAI）这三种成像模态的功能，并且可以从小鼠体内清除。同时，实验表明合成的NMOF545@Pt能够显著提高光热疗法（PTT）和放射疗法（RT）的疗效。有说服力的证据证明，肿瘤生长能够被完全抑制，且没有明显的副作用或器官损伤。结果证明了多功能纳米复合材料NMOF545@Pt在改善生物医学成像和协同肿瘤治疗方面的前景。
