Institute for Regenerative Medicine, Sechenov First Moscow State Medical University, MOSCOW, RUSSIA.
Turk Patoloji Derg. 2023;39(2):117-132. doi: 10.5146/tjpath.2022.01582.
IDH wild-type glioblastomas (GBM) are one of the most malignant and complex tumors for treatment. The urgent question of new therapeutic and diagnostic tools searching should be resolved based on cellular and molecular pathogenesis mechanisms, which remain insufficiently studied. In this study, we aimed to investigate GBM pathogenesis.
/b > Using the isolation of different GBM cell populations and the cell cultures, animal models, and molecular genetic methods, we tried to clarify the picture of GBM pathogenesis by constructing a projection from different glioma stem cells types to an integral neoplasm.
We have shown a potential transformation pathway for both glioma stem cells and four definitive cell populations during gliomagenesis. Moreover, we have characterized each population, taking into account its place in the pathogenetic continuum, with a description of the most fundamental molecular and functional properties.
Finally, we have formed a complex holistic concept of the pathogenetic evolution of GBM at the cell-population level by integrating our results with the data of the world literature.
异柠檬酸脱氢酶野生型脑胶质瘤（GBM）是治疗中最恶性和最复杂的肿瘤之一。新的治疗和诊断工具的探索应该基于细胞和分子发病机制来解决，而这些机制仍研究不足。本研究旨在探讨 GBM 的发病机制。
/b > 通过分离不同的 GBM 细胞群和细胞培养、动物模型以及分子遗传方法，我们试图通过从不同的神经胶质瘤干细胞类型到整体肿瘤构建投影来阐明 GBM 发病机制的情况。
我们已经显示了在神经胶质瘤发生过程中，神经胶质瘤干细胞和四种确定的细胞群都具有潜在的转化途径。此外，我们还对每个群体进行了特征描述，考虑到其在发病连续体中的位置，并描述了最基本的分子和功能特性。
最后，我们通过将我们的结果与世界文献数据相结合，在细胞群体水平上形成了 GBM 发病演变的复杂整体概念。
