Centre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Level 1, 32 Gisborne Street, East Melbourne, VIC, 3002, Australia.
Department of Ophthalmology, Faculty of Medicine, Assiut University, Assiut, Egypt.
Int Ophthalmol. 2023 Jan;43(1):207-214. doi: 10.1007/s10792-022-02417-z. Epub 2022 Jul 25.
To evaluate the acute effects of caffeine and glucose intake on retinal vascular calibre of healthy adults.
This prospective crossover study was conducted at the Centre for Eye Research Australia (Melbourne, Australia). Standardized doses of 300 mg caffeine (approximately 3 cups coffee), 30 g glucose or 300 ml of water, were each given to 19 healthy subjects on separate days. Retinal photographs and blood pressure measurements were taken at baseline, 30-, 60- and 120-min after ingestion of each solution. Central retinal artery and vein equivalents (CRAE, CRVE) and the arterio-venule ratio were measured using computer-assisted software. The mean retinal vascular calibre measurements were compared between pre- and post-ingestion images.
After caffeine intake, significant reductions were observed in mean CRAE of - 9.3 μm, - 10.4 μm and - 8.5 μm and CRVE of - 16.9 μm, - 18.7 μm and - 16.1 μm at 30-, 60- and 120-min after intake when compared with baseline (p ≤ 0.002 for all; paired t test). No significant changes were observed in mean retinal vascular calibre measurements after intake of either glucose or water when compared to baseline (p ≥ 0.072 for all). When controlling for baseline characteristics and blood pressure measurements, only caffeine intake had a significant effect on reducing both CRAE and CRVE at all time points post ingestion (p ≤ 0.003 for all, multiple linear regression model).
Caffeine is associated with an acute vasoconstrictive effect on retinal arterioles and venules in healthy subjects. Factors other than blood pressure-induced autoregulation play a significant role in caffeine-associated retinal vasoconstriction.
评估健康成年人摄入咖啡因和葡萄糖对视网膜血管口径的急性影响。
这是一项在澳大利亚眼研究中心（澳大利亚墨尔本）进行的前瞻性交叉研究。在不同的日子里，19 名健康受试者分别摄入 300mg 咖啡因（约 3 杯咖啡）、30g 葡萄糖或 300ml 水。在摄入每种溶液前、后 30、60 和 120 分钟时，拍摄视网膜照片并测量血压。使用计算机辅助软件测量中心视网膜动脉和静脉等效物（CRAE、CRVE）和动静脉比。比较摄入前后图像的平均视网膜血管口径测量值。
摄入咖啡因后，与基线相比，在 30、60 和 120 分钟时，CRAE 的平均下降幅度分别为-9.3μm、-10.4μm 和-8.5μm，CRVE 的平均下降幅度分别为-16.9μm、-18.7μm 和-16.1μm（p≤0.002 均）。与基线相比，摄入葡萄糖或水后，平均视网膜血管口径测量值没有显著变化（p≥0.072 均）。在控制基线特征和血压测量值后，只有咖啡因摄入在摄入后所有时间点对降低 CRAE 和 CRVE 均有显著影响（p≤0.003 均，多元线性回归模型）。
咖啡因可引起健康受试者视网膜小动脉和小静脉的急性血管收缩作用。除血压诱导的自动调节外，其他因素在咖啡因相关的视网膜血管收缩中起重要作用。
