Ozkan Berna, Yüksel Nurşen, Anik Yonca, Altintas Ozgul, Demirci Ali, Cağlar Yusuf
Department of Ophthalmology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkey.
Curr Eye Res. 2008 Sep;33(9):804-9. doi: 10.1080/02713680802344708.
To investigate the acute effect of caffeine on intraocular pressure and retrobulbar blood flow velocity.
In this randomized, double-masked, placebo-controlled, prospective study, we examined the effects of single 300-mg oral administration of caffeine on retrobulbar arteries' hemodynamics by using color Doppler ultrasonography imaging in healthy human volunteers. The subjects were divided into two groups; group 1 received a 300-mg caffeine tablet and group 2 received placebo. Measurements were obtained in two eyes at baseline, and 1 hr after acute ingestion of caffeine. Blood pressure, pulse rate, and intraocular pressure were monitored.
When compared with placebo, no significant change in mean blood pressure or intraocular pressure was observed after administration of caffeine. No significant differences were detected in the peak systolic and end diastolic velocities of retrobulbar arteries, compared with baseline values. Resistive index of ophthalmic, central retinal, and short posterior nasal ciliary artery were significantly increased after oral application of caffeine in group 1 (p<0.05).
The vascular resistance of the retrobulbar vessels appears to be altered by caffeine consumption. Further studies are needed to investigate the effects of caffeine on hemodynamics in patients with glaucoma.
研究咖啡因对眼压和球后血流速度的急性影响。
在这项随机、双盲、安慰剂对照的前瞻性研究中，我们通过彩色多普勒超声成像检查了健康人类志愿者单次口服300毫克咖啡因对球后动脉血流动力学的影响。受试者分为两组；第1组服用300毫克咖啡因片，第2组服用安慰剂。在基线时以及急性摄入咖啡因1小时后对双眼进行测量。监测血压、脉搏率和眼压。
与安慰剂相比，服用咖啡因后平均血压或眼压未观察到显著变化。与基线值相比，球后动脉的收缩期峰值和舒张末期速度未检测到显著差异。第1组口服咖啡因后，眼动脉、视网膜中央动脉和鼻睫状后短动脉的阻力指数显著增加（p<0.05）。
摄入咖啡因似乎会改变球后血管的血管阻力。需要进一步研究来调查咖啡因对青光眼患者血流动力学的影响。
