Department of Ophthalmology, Kocaeli University Medical Faculty, Kocaeli, Turkey.
Indian J Ophthalmol. 2022 Mar;70(3):879-889. doi: 10.4103/ijo.IJO_1989_21.
To observe the effects of caffeine intake on vessel densities in macular and peripapillary regions and to analyze the correlations of vascular properties of these two interlinked regions in healthy volunteers using optical coherence tomography angiography (OCTA).
In this prospective randomized, double-masked, placebo-controlled study, 120 participants were grouped into two groups: sixty subjects as a study group, which received caffeine and sixty subjects as a placebo group, which received a placebo. OCTA imaging was performed at baseline and 1 h after drug intake. Changes in macular and radial peripapillary capillary (RPC) vessel densities (VD) and foveal avascular zone (FAZ) parameters and correlation of these parameters were analyzed.
Baseline macular and RPC VD and FAZ parameters showed no significant difference between study and placebo groups (P > 0.05 for all). VD parameters in all segments of superficial and deep macular regions and peripapillary region showed a statistically significant decrease after caffeine intake (P < 0.001 for all). All macular superficial VD parameters showed a positive correlation with deep perifovea VD (P < 0.05 for all). Also, superficial perifovea VD was positively correlated with all deep macular VD parameters except deep fovea VD (P < 0.05 for all).
We show that caffeine causes a decrease in macular and peripapillary vessel densities in healthy subjects, and correlations were observed between macular and peripapillary VD parameters. We believe that future studies are needed to support the effect of caffeine on peripapillary VD and the idea of using deep perifovea VD as the main parameter to estimate superficial macular parameters.
观察咖啡因摄入对黄斑和视盘周围区域血管密度的影响，并使用光相干断层扫描血管造影术（OCTA）分析这两个相互关联区域的血管特性的相关性。
在这项前瞻性随机、双盲、安慰剂对照研究中，将 120 名参与者分为两组：60 名受试者为研究组，接受咖啡因，60 名受试者为安慰剂组，接受安慰剂。在基线和药物摄入后 1 小时进行 OCTA 成像。分析黄斑和放射状视盘周围毛细血管（RPC）血管密度（VD）和中心凹无血管区（FAZ）参数的变化以及这些参数的相关性。
研究组和安慰剂组之间黄斑和 RPC VD 和 FAZ 参数的基线值无显著差异（所有 P 值>0.05）。所有浅层和深层黄斑区域以及视盘周围区域的 VD 参数在摄入咖啡因后均有统计学显著下降（所有 P 值<0.001）。所有黄斑浅层 VD 参数与深层视盘周围 VD 呈正相关（所有 P 值<0.05）。此外，浅层视盘周围 VD 与除深层视盘中央凹 VD 外的所有深层黄斑 VD 参数呈正相关（所有 P 值<0.05）。
我们表明，咖啡因会导致健康受试者的黄斑和视盘周围血管密度降低，并观察到黄斑和视盘周围 VD 参数之间存在相关性。我们认为，需要进一步的研究来支持咖啡因对视盘周围 VD 的影响，并认为可以使用深层视盘周围 VD 作为估计浅层黄斑参数的主要参数。
