Department of Physiology and Biophysics, College of Medicine, University of Illinois, Chicago, Chicago, Illinois.
Immunology Program, Memorial Sloan Kettering Cancer Center, New York, New York.
Cancer Res. 2022 Oct 4;82(19):3409-3419. doi: 10.1158/0008-5472.CAN-22-0419.
Epithelial transformation and carcinogenesis are characterized by profound alterations in cell mechanics that significantly affect multiple steps of the metastatic cascade. The ability of cancer cells to grow in the primary tumor, to locally invade through the confining extracellular matrix, to survive in circulation, and to extravasate into distant vital organs all depend on specific mechanical characteristics. Importantly, recent studies have shown that the mechanical properties of cancer cells also influence their interactions with immune and stromal cells. Here, we discuss the mechanical changes that cancer cells undergo during metastasis, how these changes affect immune and stromal responses, and the implications of these new insights for therapeutic intervention.
上皮转化和癌变的特征是细胞力学的深刻改变，这显著影响转移级联的多个步骤。癌细胞在原发性肿瘤中生长、通过限制细胞外基质局部侵袭、在循环中存活以及渗透到远处重要器官的能力都取决于特定的力学特性。重要的是，最近的研究表明，癌细胞的机械特性也会影响它们与免疫和基质细胞的相互作用。在这里，我们讨论了癌细胞在转移过程中经历的机械变化，这些变化如何影响免疫和基质反应，以及这些新见解对治疗干预的意义。
