Department of Internal Medicine, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon-si 24289, Gangwon-do, Korea.
Department of Pathology, Kangwon National University Hospital, Kangwon National University School of Medicine, Chuncheon-si 24289, Gangwon-do, Korea.
Curr Oncol. 2022 Jun 21;29(7):4423-4427. doi: 10.3390/curroncol29070351.
The peritoneal carcinomatosis of prostate cancer without bone or other visceral organ involvement is extremely rare. We report a case of an isolated peritoneal metastasis of prostate cancer in a patient without other metastatic sites and a history of prostate surgery. A 63-year-old male with locally advanced prostate cancer without known distant metastasis on androgen deprivation therapy presented with abdominal distension that had persisted for a month. Abdominopelvic computed tomography (CT) showed gastric wall thickening and a moderate amount of ascites. The gastroscopy showed hyperemic mucosal patches on the antrum body. A cytological examination of the ascites fluid was negative for malignant cells. Diagnostic laparoscopy showed multiple nodules in the peritoneum. A biopsy was performed. Histological findings were compatible with metastatic carcinoma of the prostate, which was immunohistochemically positive for pan-cytokeratin, the androgen receptor, and prostate-specific antigen (PSA). The patient was then treated with abiraterone acetate. After 1 month of treatment, both ascites and the PSA value decreased. We describe an extremely rare case of isolated peritoneal carcinomatosis from prostate cancer without any organ metastasis or history of surgery. Clinicians should be aware of these very rare metastases of prostate cancer. Hormonal therapy may be helpful for such cases.
前列腺癌腹膜转移而无骨或其他内脏器官受累的情况极其罕见。我们报告一例前列腺癌孤立性腹膜转移的病例，该患者无其他转移部位且无前列腺手术史。一名 63 岁男性，患有局部晚期前列腺癌，在雄激素剥夺治疗期间无已知远处转移，出现持续 1 个月的腹胀。腹盆腔 CT 显示胃壁增厚和中等量腹水。胃镜检查显示胃窦体部充血性黏膜斑块。腹水细胞学检查未见恶性细胞。诊断性腹腔镜检查显示腹膜多处结节。进行了活检。组织学检查结果符合前列腺转移性癌，免疫组化显示泛细胞角蛋白、雄激素受体和前列腺特异性抗原（PSA）阳性。随后给予醋酸阿比特龙治疗。治疗 1 个月后，腹水和 PSA 值均下降。我们描述了一例非常罕见的无任何器官转移或手术史的前列腺癌孤立性腹膜转移病例。临床医生应意识到这些非常罕见的前列腺癌转移。激素治疗对此类病例可能有帮助。
