• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

1--海洋海绵中的烷基甘油醚及其细胞毒性活性。

1--Alkylglycerol Ethers from the Marine Sponge and Their Cytotoxic Activity.

机构信息

Department of Oncology, Hematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum-University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, 20251 Hamburg, Germany.

Martini-Klinik, Prostate Cancer Center, University Hospital Hamburg-Eppendorf, 20251 Hamburg, Germany.

出版信息

Mar Drugs. 2022 Jun 22;20(7):409. doi: 10.3390/md20070409.

DOI:10.3390/md20070409
PMID:35877702
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9319591/
Abstract

The cytotoxicity-bioassay-guided fractionation of the ethanol extract from the marine sponge , whose 1--alkyl--glycerol ethers (AGEs) have not been investigated so far, led to the isolation of a complex lipid fraction containing, along with previously known compounds, six new lipids of the AGE type. The composition of the AGE fraction as well as the structures of 6 new and 22 previously known compounds were established using H and C NMR, GC/MS, and chemical conversion methods. The new AGEs were identified as: 1--(Z-docos-15-enyl)--glycerol (), 1--(Z-docos-17-enyl)--glycerol (), 1--(Z-tricos-15-enyl)--glycerol (), 1--(Z-tricos-16-enyl)--glycerol (), 1--(Z-tricos-17-enyl)--glycerol (), and 1--(Z-tetracos-15-enyl)--glycerol (). The isolated AGEs show weak cytotoxic activity in THP-1, HL-60, HeLa, DLD-1, SNU C4, SK-MEL-28, and MDA-MB-231 human cancer cells. A further cytotoxicity analysis in JB6 P Cl41 cells bearing mutated MAP kinase genes revealed that ERK2 and JNK1 play a cytoprotective role in the cellular response to the AGE-induced cytotoxic effects.

摘要

迄今尚未研究过的海洋海绵乙醇提取物的细胞毒性生物测定指导的分段，导致分离出含有先前已知化合物的复杂脂质部分，以及六种新型 AGE 型脂质。使用 H 和 C NMR、GC/MS 和化学转化方法确定了 AGE 部分的组成以及 6 种新型和 22 种先前已知化合物的结构。新型 AGE 被鉴定为：1-（Z-二十二碳-15-烯基）-甘油（）、1-（Z-二十二碳-17-烯基）-甘油（）、1-（Z-二十三碳-15-烯基）-甘油（）、1-（Z-二十三碳-16-烯基）-甘油（）、1-（Z-二十三碳-17-烯基）-甘油（）和 1-（Z-二十四碳-15-烯基）-甘油（）。分离出的 AGE 在 THP-1、HL-60、HeLa、DLD-1、SNU C4、SK-MEL-28 和 MDA-MB-231 人类癌细胞中显示出较弱的细胞毒性活性。在携带突变 MAP 激酶基因的 JB6 P Cl41 细胞中进行的进一步细胞毒性分析表明，ERK2 和 JNK1 在细胞对 AGE 诱导的细胞毒性作用的反应中起细胞保护作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/9319591/48aca27619f0/marinedrugs-20-00409-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/9319591/b0df2ad9d3de/marinedrugs-20-00409-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/9319591/7716b83a8b83/marinedrugs-20-00409-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/9319591/48aca27619f0/marinedrugs-20-00409-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/9319591/b0df2ad9d3de/marinedrugs-20-00409-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/9319591/7716b83a8b83/marinedrugs-20-00409-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a306/9319591/48aca27619f0/marinedrugs-20-00409-g003.jpg

相似文献

1
1--Alkylglycerol Ethers from the Marine Sponge and Their Cytotoxic Activity.1--海洋海绵中的烷基甘油醚及其细胞毒性活性。
Mar Drugs. 2022 Jun 22;20(7):409. doi: 10.3390/md20070409.
2
Alkyl glycerol monoethers in the marine sponge Desmapsamma anchorata.海洋海绵Desmapsamma anchorata中的烷基甘油单醚。
Lipids. 1994 Oct;29(10):731-4. doi: 10.1007/BF02538919.
3
Ether-type moieties in the lipid part of glycoinositolphospholipids of Acanthamoeba rhysodes.棘阿米巴糖基肌醇磷脂脂质部分中的醚型基团。
Lipids. 2014 Apr;49(4):369-83. doi: 10.1007/s11745-014-3884-9. Epub 2014 Feb 18.
4
1-O-alkylglycerols from the hepatopancreas of the crab Paralithodes camtschaticus, liver of the squid Berryteuthis magister, and liver of the skate  Bathyraja parmifera, and their anticancer activity on human melanoma cells.来自太平洋雪蟹（Paralithodes camtschaticus）肝胰腺、短蛸（Berryteuthis magister）肝和孔鳐（Bathyraja parmifera）肝的 1-O-烷基甘油及其对人黑色素瘤细胞的抗癌活性。
J Food Biochem. 2019 May;43(5):e12828. doi: 10.1111/jfbc.12828. Epub 2019 Mar 13.
5
Ether lipids.醚脂类。
Chem Phys Lipids. 2011 Jul;164(5):315-40. doi: 10.1016/j.chemphyslip.2011.04.010. Epub 2011 May 8.
6
Phospholipid studies of marine organisms: 14. Ether lipids of the sponge Tethya aurantia.海洋生物的磷脂研究：14. 橙色海绵（Tethya aurantia）的醚脂
Lipids. 1987 Apr;22(4):236-40. doi: 10.1007/BF02533985.
7
Identification of endogenous 1-O-alk-1'-enyl-2-acyl-sn-glycerol in myocardium and its effective utilization by choline phosphotransferase.心肌中内源性1-O-烯基-1'-烯基-2-酰基-sn-甘油的鉴定及其被胆碱磷酸转移酶的有效利用。
J Biol Chem. 1988 Feb 25;263(6):2644-50.
8
Composition of O-alkyl and O-alk-1-enyl moieties in the glycerolipids of the human adrenal.人肾上腺甘油脂质中O-烷基和O-链-1-烯基部分的组成
Lipids. 1977 Jul;12(7):620-5. doi: 10.1007/BF02533392.
9
Leucanone A and naamine J, glycerol ether lipid and imidazole alkaloid from the marine sponge Leucandra sp.亮海绵素A和纳胺J，来自海洋海绵亮海绵属的甘油醚脂质和咪唑生物碱
J Asian Nat Prod Res. 2017 Jul;19(7):691-696. doi: 10.1080/10286020.2016.1240171. Epub 2016 Oct 19.
10
Simple method for the analysis of glycerol enol ethers derived from plasmalogens in complex lipid mixtures and subsequent determination of the aldehydic components by gas chromatography-mass spectrometry.用于分析复杂脂质混合物中源自缩醛磷脂的甘油烯醚并随后通过气相色谱-质谱法测定醛类成分的简单方法。
J Chromatogr. 1990 Apr 6;526(2):303-18. doi: 10.1016/s0378-4347(00)82515-3.

本文引用的文献

1
Oral Supplementation of an Alkylglycerol Mix Comprising Different Alkyl Chains Effectively Modulates Multiple Endogenous Plasmalogen Species in Mice.口服包含不同烷基链的烷基甘油混合物可有效调节小鼠体内多种内源性缩醛磷脂种类。
Metabolites. 2021 May 6;11(5):299. doi: 10.3390/metabo11050299.
2
Natural and Enantiopure Alkylglycerols as Antibiofilms Against Clinical Bacterial Isolates and Quorum Sensing Inhibitors of ATCC 12472.天然及对映体纯的烷基甘油作为针对临床细菌分离株的抗生物膜剂及ATCC 12472群体感应抑制剂
Antibiotics (Basel). 2021 Apr 13;10(4):430. doi: 10.3390/antibiotics10040430.
3
Gracilosulfates A-G, Monosulfated Polyoxygenated Steroids from the Marine Sponge .
格罗沙硫酯 A-G，海洋海绵来源的单硫酸化多氧化甾醇
Mar Drugs. 2020 Aug 30;18(9):454. doi: 10.3390/md18090454.
4
Plasmalogens, platelet-activating factor and beyond - Ether lipids in signaling and neurodegeneration.醚脂类在信号转导和神经退行性变中的作用：血小板激活因子和其他相关物质。
Neurobiol Dis. 2020 Nov;145:105061. doi: 10.1016/j.nbd.2020.105061. Epub 2020 Aug 28.
5
Marine alkaloid monanchoxymycalin C: a new specific activator of JNK1/2 kinase with anticancer properties.海洋生物碱单鞍酮酰基苦参碱 C：一种新型特异性 JNK1/2 激酶激活剂，具有抗癌特性。
Sci Rep. 2020 Aug 6;10(1):13178. doi: 10.1038/s41598-020-69751-z.
6
Enantiomeric synthesis of natural alkylglycerols and their antibacterial and antibiofilm activities.天然烷基甘油的对映体合成及其抗菌和抗生物膜活性。
Nat Prod Res. 2021 Aug;35(15):2544-2550. doi: 10.1080/14786419.2019.1686370. Epub 2019 Nov 4.
7
1-O-alkylglycerols from the hepatopancreas of the crab Paralithodes camtschaticus, liver of the squid Berryteuthis magister, and liver of the skate  Bathyraja parmifera, and their anticancer activity on human melanoma cells.来自太平洋雪蟹（Paralithodes camtschaticus）肝胰腺、短蛸（Berryteuthis magister）肝和孔鳐（Bathyraja parmifera）肝的 1-O-烷基甘油及其对人黑色素瘤细胞的抗癌活性。
J Food Biochem. 2019 May;43(5):e12828. doi: 10.1111/jfbc.12828. Epub 2019 Mar 13.
8
Breast milk alkylglycerols sustain beige adipocytes through adipose tissue macrophages.母乳烷基甘油酯通过脂肪组织巨噬细胞维持米色脂肪细胞。
J Clin Invest. 2019 May 13;129(6):2485-2499. doi: 10.1172/JCI125646.
9
Neuroinflammation and adult hippocampal neurogenesis in neuropathic pain and alkyl glycerol ethers treatment in aged mice.神经炎症与成年海马神经发生在神经病理性疼痛及烷化甘油醚类药物治疗老年小鼠中的作用
Int J Mol Med. 2019 May;43(5):2153-2163. doi: 10.3892/ijmm.2019.4142. Epub 2019 Mar 21.
10
PUFA-Plasmalogens Attenuate the LPS-Induced Nitric Oxide Production by Inhibiting the NF-kB, p38 MAPK and JNK Pathways in Microglial Cells.多不饱和脂肪酸-溶血磷脂酰乙醇胺通过抑制小胶质细胞中 NF-κB、p38MAPK 和 JNK 通路减轻 LPS 诱导的一氧化氮产生。
Neuroscience. 2019 Jan 15;397:18-30. doi: 10.1016/j.neuroscience.2018.11.030. Epub 2018 Nov 26.