MOG 特异性 T 细胞反应在 SARS-CoV-2 感染前后增强，与髓鞘少突胶质细胞糖蛋白抗体相关疾病相关。
MOG-specific T cell response amplified in para- and post-SAR-CoV-2 infection in myelin oligodendrocyte glycoprotein antibody-associated disease.
机构信息
Department of Neurology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA; Autoimmunity Center of Excellence, 4015 A. Alfred Taubman Biomedical Sciences Research Building 109 Zina Pitcher Place, Ann Arbor, MI 48109, USA; Division of Rheumatology, Department of Internal Medicine, University of Michigan, Ann Arbor, MI, USA.
Department of Neurology, University of Michigan, 1500 E Medical Center Drive, Ann Arbor, MI 48109, USA; Department of Neurology, Mayo Clinic, Rochester, MN, USA.
出版信息
J Neuroimmunol. 2023 Sep 15;382:578143. doi: 10.1016/j.jneuroim.2023.578143. Epub 2023 Jul 5.
We describe clinical characteristics and deep immunophenotypes in two patients with myelin-oligodendrocyte-glycoprotein (MOG)-antibody-associated-disease after COVID-19. The para-COVID case was a 74-year-old man who developed optic neuritis two days after COVID-19. Immunological assays revealed reduced absolute CD8 T- and B-cell counts with increased frequency of NK cells. Post-COVID case was a 63-year-old man with optic neuritis six months after COVID-19, a frequency of CD8 T-cells was elevated with a relatively low fraction of naïve and a high fraction of effector memory CD8 T-cells. There was increased frequency of CD8CD38HLA-DR T-cells in the para-COVID case; interestingly, CD4CD38HLA-DR T cell frequency was increased in the post-COVID case. Both had increased SARS-CoV-2-specific and MOG-specific T-cell responses.
我们描述了两例 COVID-19 后发生的髓鞘少突胶质细胞糖蛋白 (MOG) 抗体相关疾病患者的临床特征和深度免疫表型。前 COVID-19 病例是一名 74 岁男性，在 COVID-19 后两天出现视神经炎。免疫分析显示绝对 CD8 T 细胞和 B 细胞计数减少，NK 细胞频率增加。后 COVID-19 病例是一名 63 岁男性，在 COVID-19 后 6 个月出现视神经炎，CD8 T 细胞频率升高，幼稚细胞比例相对较低，效应记忆细胞比例较高。前 COVID-19 病例中 CD8CD38HLA-DR T 细胞频率增加；有趣的是，后 COVID-19 病例中 CD4CD38HLA-DR T 细胞频率增加。两者均有增加的 SARS-CoV-2 特异性和 MOG 特异性 T 细胞反应。
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