Park Eun Jin, Park Young-Min, Lee Seung-Hwan, Kim Bongseog
Department of Psychiatry, Inje University Ilsan Paik Hospital, Goyang, Korea.
Department of Psychiatry, Inje University Sanggye Paik Hospital, Seoul, Korea.
Clin Psychopharmacol Neurosci. 2022 Aug 31;20(3):514-525. doi: 10.9758/cpn.2022.20.3.514.
The loudness dependence of the auditory evoked potential (LDAEP) is associated with central serotonergic neurotransmission. Recent studies have proposed that LDAEP is also influenced by dopaminergic activity. Evidence shows attention deficit hyperactivity disorder (ADHD) symptoms are associated with dopamine dysfunction. This study aimed to evaluate the relation between ADHD symptoms and LDAEP, as well as medication-mediated changes of LDAEP.
A total of 38 male children (6-12 years old) with ADHD were analyzed in this study. Symptom severity was assessed using the ADHD rating scale (ARS) and the continuous performance test. To determine LDAEP, the auditory event-related potential was evaluated before medication. Changes in LDAEP were measured after 12 weeks of treatment with methylphenidate.
The subjects had a mean age of 9.24 ± 1.74 years with an average IQ of 109.4 ± 13.8. Before pharmacological treatment with methylphenidate, LDAEP was positively associated with the ARS score after adjusting for age and IQ (r = 0.592, = 0.005). LDAEP was correlated with inattention (r = 0.522, = 0.015) and hyperactivity-impulsivity (r = 0.6, = 0.004). However, the LDAEP of 15 subjects decreased following methylphenidate treatment (Z = -1.988, = 0.047).
In boys with ADHD, LDAEP appears to be associated with symptom severity. LDAEP showed a significant association with impulsivity and inattention. Importantly, LDAEP was shown to decrease after drug treatment. Our findings support the utility of LDAEP as a noninvasive and clinically useful method to assess symptom severity in children with ADHD.
听觉诱发电位的响度依赖性（LDAEP）与中枢5-羟色胺能神经传递有关。最近的研究表明，LDAEP也受多巴胺能活动的影响。有证据显示，注意缺陷多动障碍（ADHD）症状与多巴胺功能障碍有关。本研究旨在评估ADHD症状与LDAEP之间的关系，以及药物介导的LDAEP变化。
本研究共分析了38名患有ADHD的男性儿童（6 - 12岁）。使用ADHD评定量表（ARS）和持续性操作测试评估症状严重程度。为了确定LDAEP，在用药前评估听觉事件相关电位。在使用哌甲酯治疗12周后测量LDAEP的变化。
受试者的平均年龄为9.24±1.74岁，平均智商为109.4±13.8。在用哌甲酯进行药物治疗前，在调整年龄和智商后，LDAEP与ARS评分呈正相关（r = 0.592，P = 0.005）。LDAEP与注意力不集中（r = 0.522，P = 0.015）和多动冲动（r = 0.6，P = 0.004）相关。然而，15名受试者在哌甲酯治疗后LDAEP降低（Z = -1.988，P = 0.047）。
在患有ADHD的男孩中，LDAEP似乎与症状严重程度有关。LDAEP与冲动和注意力不集中有显著关联。重要的是，药物治疗后LDAEP降低。我们的研究结果支持LDAEP作为一种评估ADHD儿童症状严重程度的非侵入性且临床有用方法的实用性。
