School of Public Health, North China University of Science and Technology, Caofeidian Dis, Bohai Road 21, Tangshan, 063210, People's Republic of China.
Cell Commun Signal. 2022 Jul 25;20(1):112. doi: 10.1186/s12964-022-00924-1.
Osteoporosis is a common skeletal disease with marked bone loss, deterioration of the bone microstructure and bone fragility. An abnormal bone remodelling cycle with relatively increased bone resorption is the crucial pathophysiological mechanism. Bone remodelling is predominantly controlled by osteoblasts and osteoclasts, which are specialized cell types that are regulated by a variety of osteogenic and osteoclastic factors, including cytokines expressed within the bone microenvironment under local or systemic inflammatory conditions. Signal transducer and activator of transcription 3 (STAT3) plays a prominent role in the communication between cytokines and kinases by binding downstream gene promotors and is involved in a wide range of biological or pathological processes. Emerging evidence suggests that STAT3 and its network participate in bone remodelling and the development of osteoporosis, and this factor may be a potent target for osteoporosis treatment. This review focuses on the role and molecular mechanism of the STAT3 signalling pathway in osteogenesis, osteoclastogenesis and osteoporosis, particularly the bone-related cytokines that regulate the osteoblastic differentiation of bone marrow stromal cells and the osteoclastic differentiation of bone marrow macrophages by initiating STAT3 signalling. This review also examines the cellular interactions among immune cells, haematopoietic cells and osteoblastic/osteoclastic cells. Video abstract.
骨质疏松症是一种常见的骨骼疾病，其特征是明显的骨丢失、骨微观结构恶化和骨脆弱。异常的骨重塑周期，伴有相对增加的骨吸收，是关键的病理生理机制。骨重塑主要由成骨细胞和破骨细胞控制，这是两种专门的细胞类型，受多种成骨和破骨因子的调节，包括在局部或全身炎症条件下骨微环境中表达的细胞因子。信号转导子和转录激活子 3（STAT3）通过结合下游基因启动子，在细胞因子和激酶之间的通讯中发挥重要作用，并参与广泛的生物学或病理过程。新出现的证据表明，STAT3 及其网络参与骨重塑和骨质疏松症的发生，该因子可能是骨质疏松症治疗的有效靶点。本综述重点介绍 STAT3 信号通路在成骨、破骨和成骨 疏松症中的作用和分子机制，特别是通过启动 STAT3 信号通路调节骨髓基质细胞成骨分化和骨髓巨噬细胞破骨分化的骨相关细胞因子。本综述还研究了免疫细胞、造血细胞和成骨细胞/破骨细胞之间的细胞相互作用。视频摘要。
