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Chromosomal analysis in Ewing sarcoma.

作者信息

Callen D F, Smith R D, Bourne A J

出版信息

Pathology. 1987 Jan;19(1):64-6. doi: 10.3109/00313028709065139.

DOI:10.3109/00313028709065139
PMID:3588029
Abstract

Two cases of Ewing sarcoma were karyotyped by using a fluorodeoxyuridine synchronisation procedure on short term cultures of fresh tumour material. This procedure enables rapid cytogenetic analysis of such material. Both showed relatively simple karyotypes, 48,XX, +2, +7,t(11;22)(q24;q12), ?dup(12)(q21----q24) and 47,XX,i(1q),t(11;22)(q24;q12). These results further support this translocation between chromosomes 11 and 22 as a specific marker for Ewing sarcoma. Cytogenetic studies in such cases are an important adjunct to histological studies and in some cases may contribute to the resolution of the diagnosis.

摘要

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