Brain, Immunology, and Glia Center, University of Virginia, Charlottesville, Virginia, USA.
Department of Neuroscience, University of Virginia, Charlottesville, Virginia, USA.
Immunol Rev. 2022 Oct;311(1):26-38. doi: 10.1111/imr.13120. Epub 2022 Jul 26.
The diploë region of skull has recently been discovered to act as a myeloid cell reservoir to the underlying meninges. The presence of ossified vascular channels traversing the inner skull of cortex provides a passageway for the cells to traffic from the niche, and CNS-derived antigens traveling through cerebrospinal fluid in a perivascular manner reaches the niche to signal myeloid cell egress. This review will highlight the recent findings establishing this burgeoning field along with the known role this niche plays in CNS aging and disease. It will further highlight the anatomical routes and physiological properties of the vascular structures these cells use for trafficking, spanning from skull to brain parenchyma.
颅骨的板障区最近被发现作为一个骨髓细胞库，为下面的脑膜提供支持。穿过大脑皮层内颅骨的骨化血管通道为细胞从龛中迁移提供了通道，而源自中枢神经系统的抗原通过血管周围的脑脊液运输到达龛，以信号传递给骨髓细胞。这篇综述将重点介绍最近的发现，这些发现确立了这个新兴领域的地位，同时也介绍了这个龛在中枢神经系统衰老和疾病中的已知作用。它还将重点介绍这些细胞用于迁移的血管结构的解剖途径和生理特性，范围涵盖颅骨到脑实质。
