Azizi Ahmad Farid Nikmal, Uemura Ryoko, Omori Mariko, Sueyoshi Masuo, Yasuda Masahiro
Graduate School of Medicine and Veterinary Medicine, University of Miyazaki, Miyazaki 889-2192, Japan.
Laboratory of Veterinary Anatomy, Faculty of Agriculture, University of Miyazaki, Miyazaki 889-2192, Japan.
Animals (Basel). 2022 Jul 12;12(14):1786. doi: 10.3390/ani12141786.
Growth promoting antibiotics are used in modern animal husbandry to promote growth and avoid infections. Negative effects of these antibiotics on human health are a big concern and they need to be replaced. Probiotics are expected to be a good replacement for growth promoting antibiotics. In this study, we evaluated effects of probiotics on growth and immune status of liver and secondary lymphoid organs of piglets. Body weights of probiotic-fed piglets were heavier than those of control piglets (p < 0.05) at days 30 and 45 of the experiment. Relative populations of CD4+ and IgM+ cells isolated from the liver were significantly increased (p < 0.05 and p < 0.01, respectively) in probiotic-fed piglets compared to control piglets. CD4+CD8+ T cells were significantly decreased (p < 0.05) in jejunal Peyer’s patches of treated piglets. Phagocytosis of MHC class II+ cells isolated from the liver of probiotic-fed piglets was significantly higher (p < 0.05) than that of control piglets. Phagocytosis of granulocytes isolated from the liver and peripheral blood of probiotic-fed piglets were also higher than those of control piglets. These results indicate excellent effects on growth and immune status of piglets. In conclusion, probiotics have beneficial effects on the growth and health of piglets and could be good replacement for growth promoting antibiotics.
促生长抗生素被用于现代畜牧业以促进生长并避免感染。这些抗生素对人类健康的负面影响备受关注，因此需要被替代。益生菌有望成为促生长抗生素的良好替代品。在本研究中，我们评估了益生菌对仔猪生长以及肝脏和次级淋巴器官免疫状态的影响。在实验的第30天和第45天，喂食益生菌的仔猪体重比对照仔猪更重（p < 0.05）。与对照仔猪相比，从喂食益生菌的仔猪肝脏中分离出的CD4+和IgM+细胞的相对数量显著增加（分别为p < 0.05和p < 0.01）。在经处理的仔猪空肠派尔集合淋巴结中，CD4+CD8+ T细胞显著减少（p < 0.05）。从喂食益生菌的仔猪肝脏中分离出的MHC II类+细胞的吞噬作用显著高于对照仔猪（p < 0.05）。从喂食益生菌的仔猪肝脏和外周血中分离出的粒细胞的吞噬作用也高于对照仔猪。这些结果表明益生菌对仔猪的生长和免疫状态有显著影响。总之，益生菌对仔猪的生长和健康有有益作用，并且可以成为促生长抗生素的良好替代品。
