Dhanis Joëlle, Keidan Nathaniel, Blake Dominic, Rundle Stuart, Strijker Dieuwke, van Ham Maaike, Pijnenborg Johanna M A, Smits Anke
Department of Obstetrics and Gynaecology, Radboud University Medical Centre, 6525 GA Nijmegen, The Netherlands.
Faculty of Medical Sciences, Radboud University, 6526 GA Nijmegen, The Netherlands.
Cancers (Basel). 2022 Jul 15;14(14):3448. doi: 10.3390/cancers14143448.
The literature evaluating the effect of prehabilitation programmes on postoperative outcomes and quality of life of patients with gynaecological cancer undergoing surgery was reviewed. Databases including Pubmed, Medline, EMBASE (Ovid) and PsycINFO were systematically searched to identify studies evaluating the effect of prehabilitation programmes on patients with gynaecological cancer. Both unimodal and multimodal prehabilitation programmes were included encompassing physical exercise and nutritional and psychological support. Primary outcomes were surgical complications and quality of life. Secondary outcomes were anthropometric changes and adherence to the prehabilitation programme. Seven studies fulfilled the inclusion criteria, comprising 580 patients. Included studies were nonrandomised prospective studies (n = 4), retrospective studies (n = 2) and one case report. Unimodal programmes and multimodal programmes were included. In patients with ovarian cancer, multimodal prehabilitation resulted in significantly reduced hospital stay and time to chemotherapy. In patients with endometrial and cervical cancer, prehabilitation was associated with significant weight loss, but had no significant effects on surgical complications or mortality. No adverse events of the programmes were reported. Evidence on the effect of prehabilitation for patients with gynaecological cancer is limited. Future studies are needed to determine the effects on postoperative complications and quality of life.
我们对评估术前康复计划对接受手术的妇科癌症患者术后结局和生活质量影响的文献进行了综述。系统检索了包括PubMed、Medline、EMBASE（Ovid）和PsycINFO在内的数据库，以确定评估术前康复计划对妇科癌症患者影响的研究。纳入了单峰和多峰术前康复计划，包括体育锻炼、营养和心理支持。主要结局是手术并发症和生活质量。次要结局是人体测量变化和对术前康复计划的依从性。七项研究符合纳入标准，共580例患者。纳入的研究包括非随机前瞻性研究（n = 4）、回顾性研究（n = 2）和一篇病例报告。纳入了单峰计划和多峰计划。在卵巢癌患者中，多峰术前康复显著缩短了住院时间和化疗时间。在子宫内膜癌和宫颈癌患者中，术前康复与显著体重减轻相关，但对手术并发症或死亡率无显著影响。未报告该计划的不良事件。关于术前康复对妇科癌症患者影响的证据有限。需要进一步的研究来确定其对术后并发症和生活质量的影响。
