Hong Bo Young, An Ho Jung, Lim Seong Hoon
Department of Rehabilitation Medicine, St Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Division of Medical Oncology, Department of Internal Medicine, St. Vincent's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Diagnostics (Basel). 2022 Jun 24;12(7):1542. doi: 10.3390/diagnostics12071542.
Physicians often encounter patients with unexplained muscle weakness and dysphagia. Lambert-Eaton myasthenic syndrome (LEMS) can cause unexplained weakness or dysphagia and is often accompanied by neoplastic conditions. A 64-year-old man who had several risk factors-14 kg weight loss over the last 4 years, 20 years of experience working as a coal miner, and being a 50 pack-year ex-smoker-complained of dysphagia, intermittent diplopia, mild weakness, and hypotonia. The initial computed tomography (CT) and follow-up positron emission tomography (PET) CT did not reveal any malignancy. After continuous follow-up for this LEMS, small-cell lung cancer (SCLC, cTxN1M0) was found on a serial follow-up chest CT 21 months after the LEMS diagnosis. The patient was treated with chemotherapy. LEMS is rare and is often accompanied by malignancy. This case highlights the importance of being concerned about LEMS diagnoses and of long-term follow-up for unexplained LEMS.
医生经常会遇到患有不明原因肌肉无力和吞咽困难的患者。兰伯特-伊顿肌无力综合征（LEMS）可导致不明原因的无力或吞咽困难，且常伴有肿瘤性疾病。一名64岁男性有多个风险因素——过去4年体重减轻14千克、有20年煤矿工作经历、曾吸烟50包年——主诉有吞咽困难、间歇性复视、轻度无力和肌张力减退。最初的计算机断层扫描（CT）和后续的正电子发射断层扫描（PET）CT均未发现任何恶性肿瘤。对该LEMS患者进行持续随访后，在LEMS诊断21个月后的系列胸部CT检查中发现了小细胞肺癌（SCLC，cTxN1M0）。该患者接受了化疗。LEMS很罕见，且常伴有恶性肿瘤。本病例凸显了关注LEMS诊断以及对不明原因LEMS进行长期随访的重要性。
