Chatzikostopoulos Athanasios, Moraitou Despina, Tsolaki Magdalini, Masoura Elvira, Papantoniou Georgia, Sofologi Maria, Papaliagkas Vasileios, Kougioumtzis Georgios, Papatzikis Efthymios
Neurosciences and Neurodegenerative Diseases, Postgraduate Course, Medical School, Faculty of Health Sciences, Aristotle University, 54124 Thessaloniki, Greece.
Greek Association of Alzheimer's Disease and Related Disorders (GAADRD), 54643 Thessaloniki, Greece.
Diagnostics (Basel). 2022 Jul 21;12(7):1768. doi: 10.3390/diagnostics12071768.
Episodic memory is the type of memory that allows the recollection of personal experiences containing information on what has happened and, also, where and when it happened. Because of its sensitivity to neurodegenerative diseases and the aging of the brain, it is considered a hallmark of Alzheimer's disease dementia (ADD). The objective of the present study was to examine episodic memory in amnestic mild cognitive impairment (aMCI) and ADD. Patients with the diagnosis of early aMCI, late aMCI, and mild ADD were evaluated using the Doors and People tool which consists of four subtests examining different aspects of episodic memory. The statistical analysis with receiver operating characteristic curves (ROC) showed the discriminant potential and the cutoffs of every subtest. Overall, the evaluation of episodic memory with the Doors and People tool can discriminate with great sensitivity between the different groups of people with AD and, especially, early aMCI, late aMCI, and mild ADD patients.
情景记忆是一种能够回忆个人经历的记忆类型,这些经历包含了发生了什么事情的信息,以及事情发生的地点和时间。由于其对神经退行性疾病和大脑衰老的敏感性,它被认为是阿尔茨海默病性痴呆(ADD)的一个标志。本研究的目的是检查遗忘型轻度认知障碍(aMCI)和ADD中的情景记忆。使用“门与人物”工具对诊断为早期aMCI、晚期aMCI和轻度ADD的患者进行评估,该工具由四个子测试组成,用于检查情景记忆的不同方面。采用受试者工作特征曲线(ROC)进行统计分析,显示了每个子测试的判别潜力和临界值。总体而言,使用“门与人物”工具对情景记忆进行评估,可以高度敏感地区分不同组别的AD患者,特别是早期aMCI、晚期aMCI和轻度ADD患者。