影响流感疫苗免疫原性的因素。
Factors influencing the immunogenicity of influenza vaccines.
机构信息
School of Public Health (Shenzhen), Sun Yat-sen University, Guangdong, China.
National Institute for Viral Disease Control and Prevention, Chinese Center for Disease Prevention and Control, Beijing, China.
出版信息
Hum Vaccin Immunother. 2021 Aug 3;17(8):2706-2718. doi: 10.1080/21645515.2021.1875761. Epub 2021 Mar 11.
Abstract
Annual vaccination is the best prevention of influenza. However, the immunogenicity of influenza vaccines varies among different populations. It is important to fully identify the factors that may affect the immunogenicity of the vaccines to provide best protection for vaccine recipients. This paper reviews the factors that may influence the immunogenicity of influenza vaccines from the aspects of vaccine factors, adjuvants, individual factors, repeated vaccination, and genetic factors. The confirmed or hypothesized molecular mechanisms of these factors have also been briefly summarized.
摘要
每年接种疫苗是预防流感的最佳方法。然而，不同人群接种流感疫苗的免疫原性存在差异。充分了解可能影响疫苗免疫原性的因素，可为疫苗接种者提供最佳保护。本文从疫苗因素、佐剂、个体因素、重复接种和遗传因素等方面综述了可能影响流感疫苗免疫原性的因素，并简要总结了这些因素的确认或假设的分子机制。
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