Moshirfar Majid, Kelkar Neil, Ronquillo Yasmyne C, Hoopes Phillip C
Hoopes Vision Research Center, Hoopes Vision, 11820 S. State St. #200, Draper, UT 84020, USA.
John A. Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA.
J Clin Med. 2022 Jul 19;11(14):4175. doi: 10.3390/jcm11144175.
Alpha-1 Antitrypsin Deficiency (AATD) is an autosomal inheritable disorder that impairs the protease inhibitor alpha-1 antitrypsin. This disorder presents with various systemic effects, including liver cirrhosis, centrilobular emphysema, and ocular manifestations. Performing corneal refractive surgery in patients with AATD raises concerns regarding the increased rates of corneal erosions, corneal ulcerations, potential developing descemetoceles, and other ocular manifestations. Patient outcomes for laser-assisted in situ keratomileuses (LASIK), photorefractive keratectomy (PRK), small incision lenticule extraction (SMILE), and other ocular corrective surgeries are lacking in this population. This article provides experiences performing corneal refractive surgery, discusses the current understanding of AATD, including its ocular manifestations, and explores factors to consider when evaluating patients for corneal procedures. The aim of this paper is to address the manifestations of AATD prior to performing corrective vision surgery.
α-1抗胰蛋白酶缺乏症（AATD）是一种常染色体遗传性疾病，会损害蛋白酶抑制剂α-1抗胰蛋白酶。这种疾病会产生各种全身影响，包括肝硬化、小叶中心型肺气肿和眼部表现。对AATD患者进行角膜屈光手术会引发人们对角膜糜烂、角膜溃疡、潜在的后弹力层膨出及其他眼部表现发生率增加的担忧。该人群缺乏关于准分子原位角膜磨镶术（LASIK）、准分子激光角膜切削术（PRK）、小切口基质透镜切除术（SMILE）及其他眼部矫正手术的患者预后情况。本文介绍了进行角膜屈光手术的经验，讨论了目前对AATD的认识，包括其眼部表现，并探讨了在评估患者进行角膜手术时需要考虑的因素。本文的目的是在进行矫正视力手术之前解决AATD的表现问题。
