Ianzini F, Yatvin M B
Radiat Environ Biophys. 1987;26(1):37-46. doi: 10.1007/BF01211363.
The effect of ferrous ion-ascorbate and X-radiation on multilamellar liposomes, composed of either completely saturated, unsaturated or a mixture of saturated and unsaturated fatty acids, is reported. Lipid composition is shown to be of critical importance in determining the extent to which peroxidation occurs. Liposomes composed of the mixture of saturated and unsaturated fatty acids are peroxidized to a lesser extent by ferrous ion-ascorbate. The reduced peroxidation is apparently the result of an inhibition mechanism shown by the saturated lipid component. In contrast, liposomes composed of mixed lipids do not reduce the level of peroxidation induced by ionizing radiation. These results show that the composition of liposomes plays a role in determining the extent to which peroxidation occurs when a chemical oxidant is employed, but composition is a negligible factor when ionizing radiation is the oxidant.
报道了亚铁离子 - 抗坏血酸盐和X射线辐射对由完全饱和、不饱和或饱和与不饱和脂肪酸混合物组成的多层脂质体的影响。研究表明，脂质组成对于确定过氧化发生的程度至关重要。由饱和与不饱和脂肪酸混合物组成的脂质体被亚铁离子 - 抗坏血酸盐过氧化的程度较小。过氧化程度降低显然是饱和脂质成分所表现出的抑制机制的结果。相比之下，由混合脂质组成的脂质体不会降低电离辐射诱导的过氧化水平。这些结果表明，当使用化学氧化剂时，脂质体的组成在确定过氧化发生的程度方面起作用，但当电离辐射作为氧化剂时，组成是一个可忽略不计的因素。
