Leyko W, Bartosz G
Int J Radiat Biol Relat Stud Phys Chem Med. 1986 May;49(5):743-70. doi: 10.1080/09553008514552971.
Results of numerous studies demonstrate that membranes are important sites of cell damage by both ionizing radiation and hyperthermia. Modification of membrane properties (mainly lipid fluidity) affects the cellular responses to radiation and hyperthermia but former concepts that membrane rigidification sensitizes cells to radiation while membrane fluidization potentiates hyperthermic damage have now been seriously challenged. It seems that the effects of membrane fluidity on cell responses to hyperthermia and radiation are due to an indirect influence on functional membrane proteins. The major role of lipid peroxidation in radiation damage to membranes has also been questioned. The existing evidence makes it unlikely that the interaction between radiation and hyperthermia is determined by the action of both agents on the same membrane components.
大量研究结果表明，细胞膜是电离辐射和热疗造成细胞损伤的重要部位。细胞膜特性（主要是脂质流动性）的改变会影响细胞对辐射和热疗的反应，但之前认为细胞膜僵化会使细胞对辐射敏感而细胞膜流化会增强热疗损伤的概念现在受到了严重挑战。看来细胞膜流动性对细胞热疗和辐射反应的影响是由于对功能性膜蛋白的间接影响。脂质过氧化在辐射对细胞膜损伤中的主要作用也受到了质疑。现有证据表明，辐射与热疗之间的相互作用不太可能由两种因素对相同膜成分的作用所决定。
