用于可生物降解植入物的铁纳米颗粒基大孔支架的制备与性能
Preparation and Properties of Iron Nanoparticle-Based Macroporous Scaffolds for Biodegradable Implants.
作者信息
Lozhkomoev Aleksandr S, Buyakov Ales S, Kazantsev Sergey O, Senkina Elena I, Krinitcyn Maksim G, Ivanyuk Valeria A, Sharipova Aliya F, Lerner Marat I
机构信息
Institute of Strength Physics and Materials Science of the Siberian Branch of the Russian Academy of Sciences (ISPMS SB RAS), 634021 Tomsk, Russia.
Research School of Chemistry & Applied Biomedical Sciences, National Research Tomsk Polytechnic University, 634050 Tomsk, Russia.
出版信息
Materials (Basel). 2022 Jul 14;15(14):4900. doi: 10.3390/ma15144900.
Fe-based scaffolds are of particular interest in the technology of biodegradable implants due to their high mechanical properties and biocompatibility. In the present work, using an electroexplosive Fe nanopowder and NaCl particles 100-200 µm in size as a porogen, scaffolds with a porosity of about 70 ± 0.8% were obtained. The effect of the sintering temperature on the structure, composition, and mechanical characteristics of the scaffolds was considered. The optimum parameters of the sintering process were determined, allowing us to obtain samples characterized by plastic deformation and a yield strength of up to 16.2 MPa. The degradation of the scaffolds sintered at 1000 and 1100 °C in 0.9 wt.% NaCl solution for 28 days resulted in a decrease in their strength by 23% and 17%, respectively.
由于具有高机械性能和生物相容性，铁基支架在可生物降解植入物技术中备受关注。在本工作中，使用电爆炸铁纳米粉末和尺寸为100 - 200 µm的氯化钠颗粒作为致孔剂，获得了孔隙率约为70±0.8%的支架。研究了烧结温度对支架结构、组成和力学特性的影响。确定了烧结过程的最佳参数，从而能够获得具有塑性变形且屈服强度高达16.2 MPa的样品。在0.9 wt.%氯化钠溶液中，1000℃和1100℃烧结的支架经过28天的降解后，其强度分别降低了23%和17%。
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