Yan'an University, Key Laboratory of Microbial Drugs Innovation and Transformation, Yan'an, Shaanxi, China.
Chengdu Medical College, Non-coding RNA and Drug Discovery Key Laboratory of Sichuan Province, Chengdu, Sichuan, China.
PeerJ. 2022 Jul 21;10:e13738. doi: 10.7717/peerj.13738. eCollection 2022.
, the main conditional pathogen causing nosocomial infection, is a gram-negative bacterium with the largest genome among the known bacteria. The main reasons why is prone to drug-resistant strains in clinic are: the drug-resistant genes in its genome and the drug resistance easily induced by single antibiotic treatment. With the development of high-throughput sequencing technology and bioinformatics, the functions of various small RNAs (sRNA) in are being revealed. Different sRNAs regulate gene expression by binding to protein or mRNA to play an important role in the complex regulatory network. In this article, first, the importance and biological functions of different sRNAs in are explored, and then the evidence and possibilities that sRNAs served as drug therapeutic targets are discussed, which may introduce new directions to develop novel disease treatment strategies.
铜绿假单胞菌是导致医院感染的主要条件致病菌，是已知细菌中基因组最大的革兰氏阴性菌。临床上铜绿假单胞菌容易产生耐药菌株的主要原因有：其基因组中存在耐药基因和单一抗生素治疗容易诱导耐药性。随着高通量测序技术和生物信息学的发展，铜绿假单胞菌中各种小 RNA（sRNA）的功能逐渐被揭示。不同的 sRNA 通过与蛋白质或 mRNA 结合来调节基因表达，在复杂的调控网络中发挥重要作用。本文首先探讨了不同 sRNA 在铜绿假单胞菌中的重要性和生物学功能，然后讨论了 sRNA 作为药物治疗靶点的证据和可能性，这可能为开发新型疾病治疗策略提供新的方向。
