Fadel Celine A, Kanakamedala Swathi, Danak Shivang U, Johnson Andrew T
Internal Medicine, Northeast Georgia Medical Center Gainesville, Gainesville, USA.
Hematology-Oncology, Longstreet Clinic Cancer Center, Gainesville, USA.
Cureus. 2022 Jun 21;14(6):e26146. doi: 10.7759/cureus.26146. eCollection 2022 Jun.
Uveal melanoma (UM) is an intraocular malignancy with poor survival rates due to the propensity for metastatic spread. Although treatment options exist for localized disease, there are fewer definitive guidelines for metastatic UM. Treatment involves a personalized approach that entails patient-specific aspects, including tumor genetics. This case highlights the disease course of a 60-year-old male diagnosed with stage IIB right eye choroidal melanoma. Despite successful therapy for localized UM, he developed widespread metastasis. He received dual immunotherapy and was ultimately maintained on a single-agent regimen. His prognosis has surpassed initial prognosis and survival expectations. This case highlights the use of immunotherapy, both dual and single therapy, to treat this rare malignancy and extend overall survival.
葡萄膜黑色素瘤（UM）是一种眼内恶性肿瘤，由于其易于发生转移扩散，生存率较低。尽管对于局限性疾病存在治疗选择，但对于转移性UM的明确指南较少。治疗采用个性化方法，需要考虑患者的具体情况，包括肿瘤遗传学。本病例突出了一名60岁男性被诊断为IIB期右眼脉络膜黑色素瘤的疾病过程。尽管局限性UM的治疗取得了成功，但他仍发生了广泛转移。他接受了双重免疫治疗，最终维持单药治疗方案。他的预后超过了最初的预后和生存预期。本病例突出了使用双重和单一免疫疗法治疗这种罕见恶性肿瘤并延长总生存期的情况。
