Alhammadi Nouf, Asiri Abdullah H, Alshahrani Fatimah M, Alqahtani Alhanouf Y, Al Qout Maraam M, Alnami Raad A, Alasiri Ahlam S, Al-Zomia Ahmed S
Internal Medicine, King Khalid University, Abha, SAU.
Medicine and Surgery, King Khalid University, Abha, SAU.
Cureus. 2022 Jun 21;14(6):e26154. doi: 10.7759/cureus.26154. eCollection 2022 Jun.
Background Traditional non-steroidal anti-inflammatory drugs (NSAIDs) are recognized to injure the upper gastrointestinal tract (GIT) mucosa. For example, gastric mucosal hemorrhages can be caused by a single dose of 650 mg of aspirin. Nearly 30% to 50% of NSAID users showed endoscopic lesions including subepithelial hemorrhages, erosions, and ulcerations. These lesions are often asymptomatic and are mostly found in the gastric antrum. With the chronic exposure, the mucosa adapts to the aggression of the NSAIDs, whereby these lesions slowly lessen or fade. Aim The aim of this study is to detect the association between NSAIDs and gastrointestinal complications among the general population in the Aseer region, Saudi Arabia. Methodology A record-based retrospective study was conducted targeting people with GIT complications who were 20 years old and above. We reviewed patients' records from the GIT clinic in the Aseer region of Saudi Arabia. We reviewed specifically patients who had GIT complications like gastritis, abdominal pain, GIT bleeding, heartburn, nausea, vomiting, peptic ulcer, and diarrhea. Then we contacted those patients individually to fill out a questionnaire. Participants less than 18 years, those who refused to complete the questionnaire, or any patients with no history of GIT complications were excluded. An online questionnaire was sent to the patients with GIT complications. The questionnaire included participant's personal data, NSAID use, and associated GIT complications. The questionnaire was uploaded online using social media platforms by the researchers and their relatives and friends during the period from March 2012 to May 2022. Results A total of 211 participants with GIT complications completed the study questionnaire. Participant ages ranged from 20-59 years with a mean age of 31.2 ± 12.9 years old. A total of 140 (66.4%) were males and 175 (82.9%) were from urban areas. A total of 156 (73.9%) were non-smokers. A total of 103 (48.8%) participants used NSAIDs. As for complications, the most reported were peptic ulcer (37.9%), GIT bleeding (5.8%), GIT erosions (4.9%), and intestinal obstruction (3.9%) while 59.2% had no complications. Conclusions The current study revealed that nearly one out of every two participants in the Aseer region mainly used NSAIDs as tablets for pain. Regarding high utilization rates, less than half of them developed GIT complications, mainly peptic ulcers.
背景 传统非甾体抗炎药（NSAIDs）被认为会损伤上消化道（GIT）黏膜。例如，单次服用650毫克阿司匹林就可能导致胃黏膜出血。近30%至50%的NSAIDs使用者出现内镜下病变，包括上皮下出血、糜烂和溃疡。这些病变通常无症状，大多位于胃窦部。随着长期接触，黏膜会适应NSAIDs的侵害，从而这些病变会慢慢减轻或消退。目的 本研究的目的是检测沙特阿拉伯阿西尔地区普通人群中NSAIDs与胃肠道并发症之间的关联。方法 开展一项基于记录的回顾性研究，针对20岁及以上有GIT并发症的人群。我们查阅了沙特阿拉伯阿西尔地区GIT诊所的患者记录。我们特别查阅了患有胃炎、腹痛、GIT出血、烧心、恶心、呕吐、消化性溃疡和腹泻等GIT并发症的患者。然后我们分别联系这些患者填写一份问卷。排除年龄小于18岁的参与者、拒绝完成问卷的参与者或任何无GIT并发症病史的患者。向有GIT并发症的患者发送一份在线问卷。问卷包括参与者的个人数据、NSAIDs使用情况以及相关的GIT并发症。在2012年3月至2022年5月期间，研究人员及其亲朋好友通过社交媒体平台将问卷在线上传。结果 共有211名有GIT并发症的参与者完成了研究问卷。参与者年龄在20至59岁之间，平均年龄为31.2±12.9岁。共有140名（66.4%）为男性，175名（82.9%）来自城市地区。共有156名（73.9%）不吸烟。共有103名（48.8%）参与者使用NSAIDs。至于并发症，报告最多的是消化性溃疡（37.9%）、GIT出血（5.8%）、GIT糜烂（4.9%）和肠梗阻（3.9%），而59.2%的人无并发症。结论 目前的研究表明，阿西尔地区每两名参与者中就有近一人主要将NSAIDs作为止痛片使用。在高使用率的情况下，其中不到一半的人出现了GIT并发症，主要是消化性溃疡。
