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新冠患者综合康复中线粒体功能障碍的纠正

Correction of Mitochondrial Dysfunction in the Complex Rehabilitation of COVID-19 Patients.

作者信息

Tereshin A E, Kiryanova V V, Reshetnik D A

机构信息

Mechnikov North-Western State Medical University, Russian Ministry of Health, St. Petersburg, Russia.

Nikolaevskaya Hospital, St. Petersburg, Russia.

出版信息

Neurosci Behav Physiol. 2022;52(4):511-514. doi: 10.1007/s11055-022-01269-5. Epub 2022 Jul 22.

Abstract

To study the efficacy of courses of i.v., Cytoflavin in combination with the standard rehabilitation program for postcovid syndrome for correction of postcovid asthenia. Follow-up investigations were carried out in 45 patients with postcovid syndrome at the second stage of rehabilitation. Patients were divided into two groups of comparable sex and age. The volume of lung damage was also similar in both groups, at 25-80%. The 24 patients making up the comparison group received standard postcovid rehabilitation: pulsed magnetotherapy, inhalation therapy, aeroionotherapy, infrared laser therapy, courses of aerobic training, rational psychotherapy, and successive drug therapy. The 21 patients of the study group additionally received intravenous Cytoflavin daily for 10 days. The dynamics of increases in scores on the Rehabilitation Routing Scale, the Hamilton Depression Rating Scale (HDRS), the Asthenic Status Scale, and the 6-minute walk test at admission and discharge were also monitored. Addition of courses of intravenous Cytoflavin to the complex rehabilitation program for postcovid syndrome significantly improved the general functional state of the body, decreased levels of depression and asthenization, and increased physical exercise tolerance.

摘要

为研究静脉注射细胞色素C复合维生素(Cytoflavin)疗程联合标准康复方案对新冠后综合征患者新冠后乏力的纠正效果。对45例处于康复第二阶段的新冠后综合征患者进行随访调查。将患者按性别和年龄分为两组,两组肺损伤程度相似,均为25%-80%。对照组的24例患者接受标准的新冠后康复治疗:脉冲磁疗、吸入疗法、空气离子疗法、红外激光疗法、有氧运动训练疗程、合理心理治疗及序贯药物治疗。研究组的21例患者在此基础上,每天静脉注射细胞色素C复合维生素(Cytoflavin),持续10天。同时监测入院和出院时康复路径量表、汉密尔顿抑郁量表(HDRS)、虚弱状态量表及6分钟步行试验评分的变化动态。在新冠后综合征的综合康复方案中增加静脉注射细胞色素C复合维生素(Cytoflavin)疗程,可显著改善机体的整体功能状态,降低抑郁和虚弱水平,并提高身体运动耐量。

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