Ghaznavi Cyrus, Yoneoka Daisuke, Kawashima Takayuki, Eguchi Akifumi, Murakami Michio, Gilmour Stuart, Kaneko Satoshi, Kunishima Hiroyuki, Naito Wataru, Sakamoto Haruka, Maruyama-Sakurai Keiko, Takahashi Arata, Takayama Yoshihiro, Tanoue Yuta, Yamamoto Yoshiko, Yasutaka Tetsuo, Miyata Hiroaki, Nomura Shuhei
Department of Health Policy and Management, School of Medicine, Keio University, Tokyo, Japan.
Medical Education Program, Washington University School of Medicine in St Louis, Saint Louis, USA.
Lancet Reg Health West Pac. 2022 Oct;27:100540. doi: 10.1016/j.lanwpc.2022.100540. Epub 2022 Jul 21.
Research characterizing changes of heart with respect to vaccine intention is scarce, and very little research considers those who were initially vaccine willing but became hesitant. Here, we sought to assess the factors related to reversals of vaccine willingness.
We conducted a longitudinal, national survey on vaccination intention among Japanese adults aged 20 years or older, with the first questionnaire performed in February-March 2021 ( = 30,053) and the follow-up in February 2022 ( = 19,195, response rate 63.9%). The study population comprised those who reported vaccine willingness in the first survey, with the outcome variable being development of vaccine hesitancy at follow-up. We performed a regression analysis of vaccination status using sociodemographic, health-related, psychologic/attitudinal, and information-related variables as predictors. We used the sparse group minimax concave penalty (MCP) to select the optimum group of covariates for the logistic regression.
Of 11,118 (57.9%) respondents who previously expressed interest in vaccination, 10,684 (96.1%) and 434 (3.9%) were in the vaccine willing and hesitant groups, respectively. Several covariates were found to significantly predict vaccine hesitancy, including marital status, influenza vaccine history, COVID-19 infection/testing history, engagement in COVID-19 preventive measures, perceived risks/benefits of the COVID-19 vaccine, and attitudes regarding vaccination policies and norms. The use of certain information sources was also associated with vaccine hesitancy.
Sociodemographic, health-related, psychologic/attitudinal, and information-related variables predicted the development of vaccine hesitancy among those with prior willingness. Most of these predictors were also associated with vaccination status.
The present work was supported in part by a grant from the Kanagawa Prefectural Government of Japan and by AIST government subsidies.
关于心脏与疫苗接种意愿变化关系的研究较少，而且很少有研究考虑那些最初愿意接种疫苗但后来变得犹豫不决的人。在此，我们试图评估与疫苗接种意愿转变相关的因素。
我们对20岁及以上的日本成年人进行了一项关于疫苗接种意愿的纵向全国性调查，第一次问卷调查于2021年2月至3月进行（n = 30,053），2022年2月进行随访（n = 19,195，应答率63.9%）。研究人群包括在第一次调查中报告有疫苗接种意愿的人，结果变量是随访时出现的疫苗犹豫情况。我们使用社会人口学、健康相关、心理/态度和信息相关变量作为预测因素，对疫苗接种状况进行回归分析。我们使用稀疏组最小最大凹惩罚（MCP）来选择逻辑回归的最佳协变量组。
在之前表示有兴趣接种疫苗的11,118名（57.9%）受访者中，分别有10,684名（96.1%）和434名（3.9%）属于愿意接种疫苗组和犹豫接种疫苗组。发现几个协变量能显著预测疫苗犹豫情况，包括婚姻状况、流感疫苗接种史、新冠病毒感染/检测史、参与新冠病毒预防措施、对新冠病毒疫苗的感知风险/益处，以及对疫苗接种政策和规范的态度。某些信息来源的使用也与疫苗犹豫情况有关。
社会人口学、健康相关、心理/态度和信息相关变量预测了先前有意愿者中疫苗犹豫情况的出现。这些预测因素大多也与疫苗接种状况有关。
本研究部分得到了日本神奈川县政府的资助以及日本产业技术综合研究所的政府补贴。
