无症状或轻症 SARS-CoV-2 感染后的记忆 B 细胞发育。
Memory B-Cell Development After Asymptomatic or Mild Symptomatic SARS-CoV-2 Infection.
机构信息
Center for Infectious Disease and Vaccine Research, La Jolla Institute for Immunology, La Jolla, California, USA.
Naval Medical Research Center, Silver Spring, Maryland, USA.
出版信息
J Infect Dis. 2022 Dec 28;227(1):18-22. doi: 10.1093/infdis/jiac319.
Abstract
BACKGROUND
The development of memory B cells after asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is not well understood.
METHODS
We compared spike antibody titers, pseudovirus neutralizing antibody titers, and memory B-cell responses among SARS-CoV-2 PCR-positive Marine recruits who either reported asymptomatic or symptomatic infection.
RESULTS
Thirty-six asymptomatic participants exhibited similar spike IgG titers, spike IgA titers, and pseudovirus neutralization titers compared to 30 symptomatic participants. Pseudovirus neutralization and spike IgG titers showed significant positive correlations with frequency of memory B cells.
CONCLUSIONS
Among young adults, asymptomatic SARS-CoV-2 infection induced antibody and memory B-cell responses comparable to mild symptomatic infection.
摘要
背景
无症状严重急性呼吸综合征冠状病毒 2（SARS-CoV-2）感染后记忆 B 细胞的发展尚不清楚。
方法
我们比较了 SARS-CoV-2 PCR 阳性的海军新兵中报告无症状或有症状感染的个体之间的刺突抗体滴度、假病毒中和抗体滴度和记忆 B 细胞反应。
结果
36 名无症状参与者的刺突 IgG 滴度、刺突 IgA 滴度和假病毒中和滴度与 30 名有症状参与者相似。假病毒中和和刺突 IgG 滴度与记忆 B 细胞的频率呈显著正相关。
结论
在年轻人中，无症状 SARS-CoV-2 感染引起的抗体和记忆 B 细胞反应可与轻度有症状感染相媲美。
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