Institute of Animal Husbandry and Veterinary, Tibet Academy of Agricultural and Animal Husbandry Sciences, Key Laboratory of Animal Genetics and Breeding on Tibetan Plateau, Ministry of Agriculture and Rural Affairs, Lhasa, China.
School of Public Health, Lanzhou University, Lanzhou, Gansu, China.
Front Cell Infect Microbiol. 2023 Jun 23;13:1197646. doi: 10.3389/fcimb.2023.1197646. eCollection 2023.
Recent investigations show that dietary consumption of flavonoids could potentially confer neuroprotective effects through a variety of direct and indirect mechanisms. Numerous flavonoids have been shown to cross the BBB and accumulate within the central nervous system (CNS). Some of these compounds purportedly counteract the accumulation and deleterious effects of reactive oxygen species, fostering neuronal survival and proliferation by inhibiting neuroinflammatory and oxidative stress responses. Moreover, several studies suggest that gut microbiota may participate in regulating brain function and host behavior through the production and modulation of bioactive metabolites. Flavonoids may shape gut microbiota composition by acting as carbon substrates to promote the growth of beneficial bacteria that produce these neuroprotective metabolites, consequently antagonizing or suppressing potential pathogens. By influencing the microbiota-gut-brain axis through this selection process, flavonoids may indirectly improve brain health. This review examines the current state of research into the relationship between bioactive flavonoids, gut microbiota, and the gut-brain axis.
最近的研究表明，通过多种直接和间接的机制，饮食中摄入类黄酮可能具有神经保护作用。许多类黄酮已被证明可以穿过血脑屏障并在中枢神经系统 (CNS) 内积累。其中一些化合物据称可以对抗活性氧物质的积累和有害影响，通过抑制神经炎症和氧化应激反应来促进神经元的存活和增殖。此外，一些研究表明，肠道微生物群可能通过产生和调节生物活性代谢物来参与调节大脑功能和宿主行为。类黄酮可以通过作为碳底物来促进产生这些神经保护代谢物的有益细菌的生长，从而改变肠道微生物群的组成，从而拮抗或抑制潜在的病原体。通过这种选择过程影响微生物群-肠道-大脑轴，类黄酮可能间接改善大脑健康。本文综述了生物活性类黄酮、肠道微生物群和肠道-大脑轴之间关系的研究现状。
