Asma Syeda Tasmia, Imre Kálmán, Morar Adriana, Herman Viorel, Acaroz Ulas, Mukhtar Hamid, Arslan-Acaroz Damla, Shah Syed Rizwan Ali, Gerlach Robin
Department of Food Hygiene and Technology, Faculty of Veterinary Medicine, Afyon Kocatepe University, Afyonkarahisar 03200, Turkey.
Department of Animal Production and Veterinary Public Health, Faculty of Veterinary Medicine, Banat's University of Agricultural Sciences and Veterinary Medicine "King Michael I of Romania", 300645 Timisoara, Romania.
Life (Basel). 2022 Jul 23;12(8):1110. doi: 10.3390/life12081110.
Biofilm formation on surfaces via microbial colonization causes infections and has become a major health issue globally. The biofilm lifestyle provides resistance to environmental stresses and antimicrobial therapies. Biofilms can cause several chronic conditions, and effective treatment has become a challenge due to increased antimicrobial resistance. Antibiotics available for treating biofilm-associated infections are generally not very effective and require high doses that may cause toxicity in the host. Therefore, it is essential to study and develop efficient anti-biofilm strategies that can significantly reduce the rate of biofilm-associated healthcare problems. In this context, some effective combating strategies with potential anti-biofilm agents, including plant extracts, peptides, enzymes, lantibiotics, chelating agents, biosurfactants, polysaccharides, organic, inorganic, and metal nanoparticles, etc., have been reviewed to overcome biofilm-associated healthcare problems. From their extensive literature survey, it can be concluded that these molecules with considerable structural alterations might be applied to the treatment of biofilm-associated infections, by evaluating their significant delivery to the target site of the host. To design effective anti-biofilm molecules, it must be assured that the minimum inhibitory concentrations of these anti-biofilm compounds can eradicate biofilm-associated infections without causing toxic effects at a significant rate.
微生物在表面定殖形成生物膜会引发感染，已成为全球主要的健康问题。生物膜生活方式能抵抗环境压力和抗菌疗法。生物膜可导致多种慢性病，由于抗菌耐药性增加，有效治疗已成为一项挑战。用于治疗生物膜相关感染的抗生素通常效果不佳，且需要高剂量，这可能会在宿主体内产生毒性。因此，研究和开发有效的抗生物膜策略至关重要，这些策略可显著降低生物膜相关医疗问题的发生率。在此背景下，已对一些与潜在抗生物膜剂相关的有效对抗策略进行了综述，这些抗生物膜剂包括植物提取物、肽、酶、羊毛硫抗生素、螯合剂、生物表面活性剂、多糖、有机、无机和金属纳米颗粒等，以克服生物膜相关的医疗问题。通过广泛的文献调研可以得出结论，这些具有相当结构改变的分子可通过评估其向宿主靶位点的有效递送，应用于生物膜相关感染的治疗。为设计有效的抗生物膜分子，必须确保这些抗生物膜化合物的最低抑菌浓度能够根除生物膜相关感染，且不会以显著速率产生毒性作用。
