Kloc Malgorzata, Uosef Ahmed, Subuddhi Arijita, Kubiak Jacek Z, Piprek Rafal P, Ghobrial Rafik M
The Houston Methodist Research Institute, Transplant Immunology, Houston, TX 77030, USA.
The Houston Methodist Hospital, Department of Surgery, Houston, TX 77030, USA.
Biology (Basel). 2022 Jul 27;11(8):1121. doi: 10.3390/biology11081121.
This review introduces the subject of senescence, aging, and the formation of senescent multinucleated giant cells. We define senescence and aging and describe how molecular and cellular senescence leads to organismal senescence. We review the latest information on senescent cells' cellular and molecular phenotypes. We describe molecular and cellular features of aging and senescence and the role of multinucleated giant cells in aging-related conditions and cancer. We explain how multinucleated giant cells form and their role in aging arteries and gonads. We also describe how multinucleated giant cells and the reversibility of senescence initiate cancer and lead to cancer progression and metastasis. We also describe molecules and pathways regulating aging and senescence in model systems and their applicability to clinical therapies in age-related diseases.
本综述介绍了衰老、老化以及衰老多核巨细胞形成的主题。我们定义了衰老和老化，并描述了分子和细胞衰老如何导致机体衰老。我们综述了衰老细胞的细胞和分子表型的最新信息。我们描述了老化和衰老的分子和细胞特征，以及多核巨细胞在与衰老相关病症和癌症中的作用。我们解释了多核巨细胞如何形成及其在衰老动脉和性腺中的作用。我们还描述了多核巨细胞和衰老的可逆性如何引发癌症并导致癌症进展和转移。我们还描述了在模型系统中调节老化和衰老的分子和途径及其在年龄相关疾病临床治疗中的适用性。
