FSBSI North Caucasian Federal Scientific Agrarian Center, 356241 Mikhailovsk, Russia.
Federal State Autonomous Educational Institution of Higher Education North Caucasian Federal University, 355017 Stavropol, Russia.
Genes (Basel). 2022 Jul 26;13(8):1337. doi: 10.3390/genes13081337.
In a group of Jalgin merino rams with no significant influence on the dispersion of the phenotypes of known productivity genes (, , , etc.), a genome-wide search for associations of individual polymorphisms with intravital indicators of meat productivity was performed. Using the Ovine Infinium HD BeadChip 600K, 606,000 genome loci were evaluated. Twenty-three substitutions were found to be significantly associated with external measurements of the body and ultrasonic parameters. This made it possible to describe 14 candidate genes, the structural features of which can cause changes in animal phenotypes. No closely spaced genes were found for two substitutions. The identified polymorphisms were found in the exons, introns, and adjacent regions of the following genes and transcripts: , , , , , , , , , , , , , and . The detected genes affect the metabolic pathways of cell differentiation and proliferation and are associated with the regulation of the immune system. This confirms their possible participation in the formation of the phenotypes of productivity parameters in animals and indicates the need for further study of the structure of candidate genes in order to identify their internal polymorphisms.
在一组 Jalgin 美利奴公羊中，已知生产力基因（、、、等）的表型分布没有显著影响，对个体多态性与活体肉质生产力指标的关联进行了全基因组搜索。使用 Ovine Infinium HD BeadChip 600K 评估了 606,000 个基因组位点。发现 23 个替换与身体的外部测量和超声参数显著相关。这使得描述 14 个候选基因成为可能，这些基因的结构特征可能导致动物表型的变化。对于两个替换，没有发现紧密间隔的基因。鉴定出的多态性存在于以下基因和转录本的外显子、内含子和相邻区域：、、、、、、、、、、、、、。检测到的基因影响细胞分化和增殖的代谢途径，并与免疫系统的调节有关。这证实了它们可能参与动物生产力参数表型的形成，并表明需要进一步研究候选基因的结构，以确定其内部多态性。
