Kahn A, Rebuffat E, Blum D, Casimir G, Duchateau J, Mozin M J, Jost R
Sleep. 1987 Apr;10(2):116-21. doi: 10.1093/sleep/10.2.116.
To confirm that sleeplessness in infants can be related to an undiagnosed allergy to cow's milk proteins, 71 infants were studied. Group I consisted of 20 infants referred for chronic insomnia that had appeared in the early days of life. Group II was made up of 31 infants admitted for skin or digestive symptoms attributed to cow's milk intolerance; 13 of these infants were shown to sleep as poorly as the infants of group I. Group III consisted of 20 infants with no history of sleep disturbance or milk allergy. The three groups of infants were comparable for sex and age. Laboratory tests revealed immunologic reactions to milk in all the infants in groups I and II. The sleep of the insomniac infants (group I, and the 13 "poor sleepers" in group II) became normal after cow's milk was eliminated from the diet. Insomnia reappeared when the infants in group I were challenged with milk. We conclude that infants with clinically evident milk allergy may suffer from sleeplessness and that when no evident cause for a chronic insomnia can be found in an infant the possibility of milk allergy should be given serious consideration.
为了证实婴儿失眠可能与未被诊断出的牛奶蛋白过敏有关，对71名婴儿进行了研究。第一组由20名因出生早期出现慢性失眠而被转诊的婴儿组成。第二组由31名因牛奶不耐受而出现皮肤或消化症状入院的婴儿组成；其中13名婴儿的睡眠状况与第一组婴儿一样差。第三组由20名无睡眠障碍或牛奶过敏史的婴儿组成。三组婴儿在性别和年龄方面具有可比性。实验室检测显示，第一组和第二组的所有婴儿对牛奶都有免疫反应。从饮食中去除牛奶后，失眠婴儿（第一组以及第二组中的13名“睡眠不佳者”）的睡眠恢复正常。当第一组婴儿再次接触牛奶时，失眠症状再次出现。我们得出结论，临床上明显对牛奶过敏的婴儿可能会失眠，并且当在婴儿中找不到慢性失眠的明显原因时，应认真考虑牛奶过敏的可能性。
