Luo Zhengzhong, Ma Li, Zhou Tao, Huang Yixin, Zhang Liben, Du Zhenlong, Yong Kang, Yao Xueping, Shen Liuhong, Yu Shumin, Shi Xiaodong, Cao Suizhong
Key Laboratory of Coarse Cereal Processing, Ministry of Agriculture and Rural Affairs, Chengdu University, Chengdu 610106, China.
Department of Clinical Veterinary Medicine, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China.
Metabolites. 2022 Jul 26;12(8):687. doi: 10.3390/metabo12080687.
The present study aims to evaluate the alterations in gut microbiome and plasma metabolites of dairy calves with β-glucan (BG) supplementation. Fourteen healthy newborn dairy calves with similar body weight were randomly divided into control ( = 7) and BG ( = 7) groups. All the calves were fed on the basal diet, while calves in the BG group were supplemented with oat BG on d 8 for 14 days. Serum markers, fecal microbiome, and plasma metabolites at d 21 were analyzed. The calves were weaned on d 60 and weighed. The mean weaning weight of the BG group was 4.29 kg heavier than that of the control group. Compared with the control group, the levels of serum globulin, albumin, and superoxide dismutase were increased in the BG group. Oat BG intake increased the gut microbiota richness and decreased the Firmicutes-to-Bacteroidetes ratio. Changes in serum markers were found to be correlated with the plasma metabolites, including sphingosine, trehalose, and 3-methoxy-4-hydroxyphenylglycol sulfate, and gut microbiota such as , , and . Overall, these results suggest that the BG promotes growth and health of pre-weaning dairy calves by affecting the interaction between the host and gut microbiota.
本研究旨在评估补充β-葡聚糖（BG）对犊牛肠道微生物群和血浆代谢物的影响。将14头体重相近的健康新生犊牛随机分为对照组（n = 7）和BG组（n = 7）。所有犊牛均饲喂基础日粮，而BG组犊牛在第8天开始补充燕麦BG，持续14天。分析第21天的血清标志物、粪便微生物群和血浆代谢物。犊牛在第60天断奶并称重。BG组的平均断奶体重比对照组重4.29千克。与对照组相比，BG组血清球蛋白、白蛋白和超氧化物歧化酶水平升高。摄入燕麦BG增加了肠道微生物群的丰富度，降低了厚壁菌门与拟杆菌门的比例。发现血清标志物的变化与血浆代谢物（包括鞘氨醇、海藻糖和3-甲氧基-4-羟基苯乙二醇硫酸盐）以及肠道微生物群（如、、和）相关。总体而言，这些结果表明BG通过影响宿主与肠道微生物群之间的相互作用来促进断奶前犊牛的生长和健康。
