Pavitra Eluri, Lee Hoomin, Hwang Seung Kyu, Park Jin Young, Han Young-Kyu, Raju Ganji Seeta Rama, Huh Yun Suk
Department of Biological Engineering, Biohybrid Systems Research Center (BSRC), Inha University, Incheon 22212, Korea.
Department of Electrical, Electronics and Software Engineering, Pukyong National University, Yongdang Campus, Busan 48547, Korea.
Nanomaterials (Basel). 2022 Jul 22;12(15):2520. doi: 10.3390/nano12152520.
In recent times, upconversion nanomaterials with mesoporous hollow structures have gained significant interest as a prospective nano-platform for cancer imaging and therapeutic applications. In this study, we report a highly biocompatible YVO:1Er/10Yb upconversion mesoporous hollow nanospheriods (YVO:Er/Yb UC-MHNSPs) by a facile and rapid self-sacrificing template method. The Rietveld analysis confirmed their pure phase of tetragonal zircon structure. Nitrogen adsorption-desorption isotherms revealed the mesoporous nature of these UC-MHNSPs and the surface area is found to be ~87.46 m/g. Under near-infrared excitation (980 nm), YVO:Er/Yb UC-MHNSPs showed interesting color tunability from red to green emission. Initially (at 0.4 W), energy back transfer from Er to Yb ions leads to the strong red emission. Whereas at high pump powers (1 W), a fine green emission is observed due to the dominant three-photon excitation process and traditional energy transfer route from Er to Yb ions. The bright red light from the membrane of HeLa cells confirmed the effective cellular uptake of YVO:Er/Yb UC-MHNSPs. The resonant decrease in cell viability on increasing the concentration of curcumin conjugated YVO:Er/Yb UC-MHNSPs established their excellent antitumor activity. Therefore, the acquired results indicate that these YVO:Er/Yb UC-MHNSPs are promising drug carriers for bioimaging and various therapeutic applications.
近年来，具有介孔中空结构的上转换纳米材料作为一种用于癌症成像和治疗应用的潜在纳米平台，引起了广泛关注。在本研究中，我们通过一种简便快速的自牺牲模板法，报道了一种具有高度生物相容性的YVO:1Er/10Yb上转换介孔中空纳米球（YVO:Er/Yb UC-MHNSPs）。Rietveld分析证实了它们为四方锆结构的纯相。氮吸附-脱附等温线揭示了这些UC-MHNSPs的介孔性质，其表面积约为87.46 m/g。在近红外激发（980 nm）下，YVO:Er/Yb UC-MHNSPs表现出从红色到绿色发射的有趣颜色可调性。最初（在0.4 W时），从Er到Yb离子的能量反向转移导致强烈的红色发射。而在高泵浦功率（1 W）下，由于占主导地位的三光子激发过程以及从Er到Yb离子的传统能量转移途径，观察到了精细的绿色发射。来自HeLa细胞膜的明亮红光证实了YVO:Er/Yb UC-MHNSPs的有效细胞摄取。随着姜黄素共轭YVO:Er/Yb UC-MHNSPs浓度的增加，细胞活力的共振下降证实了它们优异的抗肿瘤活性。因此，所获得的结果表明，这些YVO:Er/Yb UC-MHNSPs是用于生物成像和各种治疗应用的有前景的药物载体。
